HDAC8-PHKA1 Fusion FISH Probe
The HDAC8-PHKA1 Fusion FISH Probe is used to confirm a fusion of the HDAC8 and PHKA1 genes. The fusion of the HDAC8 and PHKA1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HDAC8-PHKA1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HDAC8-PHKA1-20-RERE | 20 (40 μL) | 200 μL |
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| HDAC8-PHKA1-20-REOR | 20 (40 μL) | 200 μL |
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| HDAC8-PHKA1-20-REGO | 20 (40 μL) | 200 μL |
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| HDAC8-PHKA1-20-REGR | 20 (40 μL) | 200 μL |
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| HDAC8-PHKA1-20-REAQ | 20 (40 μL) | 200 μL |
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| HDAC8-PHKA1-20-ORRE | 20 (40 μL) | 200 μL |
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| HDAC8-PHKA1-20-OROR | 20 (40 μL) | 200 μL |
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| HDAC8-PHKA1-20-ORGO | 20 (40 μL) | 200 μL |
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| HDAC8-PHKA1-20-ORAQ | 20 (40 μL) | 200 μL |
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| HDAC8-PHKA1-20-GORE | 20 (40 μL) | 200 μL |
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| HDAC8-PHKA1-20-GOOR | 20 (40 μL) | 200 μL |
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| HDAC8-PHKA1-20-GOGO | 20 (40 μL) | 200 μL |
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| HDAC8-PHKA1-20-GOGR | 20 (40 μL) | 200 μL |
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| HDAC8-PHKA1-20-GOAQ | 20 (40 μL) | 200 μL |
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| HDAC8-PHKA1-20-GRRE | 20 (40 μL) | 200 μL |
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| HDAC8-PHKA1-20-GROR | 20 (40 μL) | 200 μL |
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| HDAC8-PHKA1-20-GRGO | 20 (40 μL) | 200 μL |
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| HDAC8-PHKA1-20-GRGR | 20 (40 μL) | 200 μL |
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| HDAC8-PHKA1-20-GRAQ | 20 (40 μL) | 200 μL |
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| HDAC8-PHKA1-20-AQRE | 20 (40 μL) | 200 μL |
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| HDAC8-PHKA1-20-AQOR | 20 (40 μL) | 200 μL |
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| HDAC8-PHKA1-20-AQGO | 20 (40 μL) | 200 μL |
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| HDAC8-PHKA1-20-AQGR | 20 (40 μL) | 200 μL |
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| HDAC8-PHKA1-20-AQAQ | 20 (40 μL) | 200 μL |
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PHKA1 Gene Summary
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the skeletal muscle isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9D, also known as X-linked muscle glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. A pseudogene has been found on chromosome 1.[provided by RefSeq, Feb 2010]
Gene Name: Phosphorylase Kinase Regulatory Subunit Alpha 1
Chromosome: CHRX: 71798663 -71934029
Locus: Xq13.1
HDAC8 Gene Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Name: Histone Deacetylase 8
Chromosome: CHRX: 71549365 -71792953
Locus: Xq13.1
Gene Diseases
The HDAC8 PHKA1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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