HDAC7-IRAK4 Fusion FISH Probe
The HDAC7-IRAK4 Fusion FISH Probe is used to confirm a fusion of the HDAC7 and IRAK4 genes. The fusion of the HDAC7 and IRAK4 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HDAC7-IRAK4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HDAC7-IRAK4-20-RERE | 20 (40 μL) | 200 μL |
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| HDAC7-IRAK4-20-REOR | 20 (40 μL) | 200 μL |
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| HDAC7-IRAK4-20-REGO | 20 (40 μL) | 200 μL |
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| HDAC7-IRAK4-20-REGR | 20 (40 μL) | 200 μL |
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| HDAC7-IRAK4-20-REAQ | 20 (40 μL) | 200 μL |
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| HDAC7-IRAK4-20-ORRE | 20 (40 μL) | 200 μL |
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| HDAC7-IRAK4-20-OROR | 20 (40 μL) | 200 μL |
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| HDAC7-IRAK4-20-ORGO | 20 (40 μL) | 200 μL |
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| HDAC7-IRAK4-20-ORAQ | 20 (40 μL) | 200 μL |
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| HDAC7-IRAK4-20-GORE | 20 (40 μL) | 200 μL |
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| HDAC7-IRAK4-20-GOOR | 20 (40 μL) | 200 μL |
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| HDAC7-IRAK4-20-GOGO | 20 (40 μL) | 200 μL |
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| HDAC7-IRAK4-20-GOGR | 20 (40 μL) | 200 μL |
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| HDAC7-IRAK4-20-GOAQ | 20 (40 μL) | 200 μL |
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| HDAC7-IRAK4-20-GRRE | 20 (40 μL) | 200 μL |
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| HDAC7-IRAK4-20-GROR | 20 (40 μL) | 200 μL |
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| HDAC7-IRAK4-20-GRGO | 20 (40 μL) | 200 μL |
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| HDAC7-IRAK4-20-GRGR | 20 (40 μL) | 200 μL |
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| HDAC7-IRAK4-20-GRAQ | 20 (40 μL) | 200 μL |
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| HDAC7-IRAK4-20-AQRE | 20 (40 μL) | 200 μL |
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| HDAC7-IRAK4-20-AQOR | 20 (40 μL) | 200 μL |
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| HDAC7-IRAK4-20-AQGO | 20 (40 μL) | 200 μL |
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| HDAC7-IRAK4-20-AQGR | 20 (40 μL) | 200 μL |
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| HDAC7-IRAK4-20-AQAQ | 20 (40 μL) | 200 μL |
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IRAK4 Gene Summary
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Name: Interleukin 1 Receptor Associated Kinase 4
Chromosome: CHR12: 44152746 -44183346
Locus: 12q12
HDAC7 Gene Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Histone Deacetylase 7
Chromosome: CHR12: 48176506 -48213763
Locus: 12q13.11
Gene Diseases
The HDAC7 IRAK4 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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