HDAC5-MYO18A Fusion FISH Probe
The HDAC5-MYO18A Fusion FISH Probe is used to confirm a fusion of the HDAC5 and MYO18A genes. The fusion of the HDAC5 and MYO18A genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HDAC5-MYO18A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HDAC5-MYO18A-20-RERE | 20 (40 μL) | 200 μL |
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| HDAC5-MYO18A-20-REOR | 20 (40 μL) | 200 μL |
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| HDAC5-MYO18A-20-REGO | 20 (40 μL) | 200 μL |
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| HDAC5-MYO18A-20-REGR | 20 (40 μL) | 200 μL |
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| HDAC5-MYO18A-20-REAQ | 20 (40 μL) | 200 μL |
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| HDAC5-MYO18A-20-ORRE | 20 (40 μL) | 200 μL |
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| HDAC5-MYO18A-20-OROR | 20 (40 μL) | 200 μL |
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| HDAC5-MYO18A-20-ORGO | 20 (40 μL) | 200 μL |
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| HDAC5-MYO18A-20-ORAQ | 20 (40 μL) | 200 μL |
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| HDAC5-MYO18A-20-GORE | 20 (40 μL) | 200 μL |
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| HDAC5-MYO18A-20-GOOR | 20 (40 μL) | 200 μL |
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| HDAC5-MYO18A-20-GOGO | 20 (40 μL) | 200 μL |
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| HDAC5-MYO18A-20-GOGR | 20 (40 μL) | 200 μL |
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| HDAC5-MYO18A-20-GOAQ | 20 (40 μL) | 200 μL |
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| HDAC5-MYO18A-20-GRRE | 20 (40 μL) | 200 μL |
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| HDAC5-MYO18A-20-GROR | 20 (40 μL) | 200 μL |
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| HDAC5-MYO18A-20-GRGO | 20 (40 μL) | 200 μL |
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| HDAC5-MYO18A-20-GRGR | 20 (40 μL) | 200 μL |
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| HDAC5-MYO18A-20-GRAQ | 20 (40 μL) | 200 μL |
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| HDAC5-MYO18A-20-AQRE | 20 (40 μL) | 200 μL |
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| HDAC5-MYO18A-20-AQOR | 20 (40 μL) | 200 μL |
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| HDAC5-MYO18A-20-AQGO | 20 (40 μL) | 200 μL |
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| HDAC5-MYO18A-20-AQGR | 20 (40 μL) | 200 μL |
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| HDAC5-MYO18A-20-AQAQ | 20 (40 μL) | 200 μL |
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HDAC5 Gene Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Histone Deacetylase 5
Chromosome: CHR17: 42154120 -42201014
Locus: 17q21.31
MYO18A Gene Summary
The protein encoded by this gene can bind GOLPH3, linking the Golgi to the cytoskeleton and influencing Golgi membrane trafficking. The encoded protein is also part of a complex that assembles lamellar actomyosin bundles and may be required for cell migration. [provided by RefSeq, Oct 2016]
Gene Name: Myosin XVIIIA
Chromosome: CHR17: 27400527 -27507407
Locus: 17q11.2
Gene Diseases
The HDAC5 MYO18A Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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