HDAC4-UPB1 Fusion FISH Probe
The HDAC4-UPB1 Fusion FISH Probe is used to confirm a fusion of the HDAC4 and UPB1 genes. The fusion of the HDAC4 and UPB1 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HDAC4-UPB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HDAC4-UPB1-20-RERE | 20 (40 μL) | 200 μL |
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| HDAC4-UPB1-20-REOR | 20 (40 μL) | 200 μL |
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| HDAC4-UPB1-20-REGO | 20 (40 μL) | 200 μL |
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| HDAC4-UPB1-20-REGR | 20 (40 μL) | 200 μL |
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| HDAC4-UPB1-20-REAQ | 20 (40 μL) | 200 μL |
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| HDAC4-UPB1-20-ORRE | 20 (40 μL) | 200 μL |
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| HDAC4-UPB1-20-OROR | 20 (40 μL) | 200 μL |
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| HDAC4-UPB1-20-ORGO | 20 (40 μL) | 200 μL |
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| HDAC4-UPB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| HDAC4-UPB1-20-GORE | 20 (40 μL) | 200 μL |
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| HDAC4-UPB1-20-GOOR | 20 (40 μL) | 200 μL |
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| HDAC4-UPB1-20-GOGO | 20 (40 μL) | 200 μL |
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| HDAC4-UPB1-20-GOGR | 20 (40 μL) | 200 μL |
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| HDAC4-UPB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| HDAC4-UPB1-20-GRRE | 20 (40 μL) | 200 μL |
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| HDAC4-UPB1-20-GROR | 20 (40 μL) | 200 μL |
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| HDAC4-UPB1-20-GRGO | 20 (40 μL) | 200 μL |
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| HDAC4-UPB1-20-GRGR | 20 (40 μL) | 200 μL |
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| HDAC4-UPB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| HDAC4-UPB1-20-AQRE | 20 (40 μL) | 200 μL |
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| HDAC4-UPB1-20-AQOR | 20 (40 μL) | 200 μL |
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| HDAC4-UPB1-20-AQGO | 20 (40 μL) | 200 μL |
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| HDAC4-UPB1-20-AQGR | 20 (40 μL) | 200 μL |
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| HDAC4-UPB1-20-AQAQ | 20 (40 μL) | 200 μL |
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HDAC4 Gene Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
Gene Name: Histone Deacetylase 4
Chromosome: CHR2: 239969863 -240322643
Locus: 2q37.3
UPB1 Gene Summary
This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity. [provided by RefSeq, Jul 2008]
Gene Name: Beta-ureidopropionase 1
Chromosome: CHR22: 24891250 -24922553
Locus: 22q11.23
Gene Diseases
The HDAC4 UPB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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