HDAC4-SNX18 Fusion FISH Probe
The HDAC4-SNX18 Fusion FISH Probe is used to confirm a fusion of the HDAC4 and SNX18 genes. The fusion of the HDAC4 and SNX18 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HDAC4-SNX18-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HDAC4-SNX18-20-RERE | 20 (40 μL) | 200 μL |
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| HDAC4-SNX18-20-REOR | 20 (40 μL) | 200 μL |
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| HDAC4-SNX18-20-REGO | 20 (40 μL) | 200 μL |
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| HDAC4-SNX18-20-REGR | 20 (40 μL) | 200 μL |
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| HDAC4-SNX18-20-REAQ | 20 (40 μL) | 200 μL |
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| HDAC4-SNX18-20-ORRE | 20 (40 μL) | 200 μL |
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| HDAC4-SNX18-20-OROR | 20 (40 μL) | 200 μL |
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| HDAC4-SNX18-20-ORGO | 20 (40 μL) | 200 μL |
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| HDAC4-SNX18-20-ORAQ | 20 (40 μL) | 200 μL |
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| HDAC4-SNX18-20-GORE | 20 (40 μL) | 200 μL |
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| HDAC4-SNX18-20-GOOR | 20 (40 μL) | 200 μL |
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| HDAC4-SNX18-20-GOGO | 20 (40 μL) | 200 μL |
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| HDAC4-SNX18-20-GOGR | 20 (40 μL) | 200 μL |
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| HDAC4-SNX18-20-GOAQ | 20 (40 μL) | 200 μL |
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| HDAC4-SNX18-20-GRRE | 20 (40 μL) | 200 μL |
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| HDAC4-SNX18-20-GROR | 20 (40 μL) | 200 μL |
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| HDAC4-SNX18-20-GRGO | 20 (40 μL) | 200 μL |
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| HDAC4-SNX18-20-GRGR | 20 (40 μL) | 200 μL |
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| HDAC4-SNX18-20-GRAQ | 20 (40 μL) | 200 μL |
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| HDAC4-SNX18-20-AQRE | 20 (40 μL) | 200 μL |
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| HDAC4-SNX18-20-AQOR | 20 (40 μL) | 200 μL |
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| HDAC4-SNX18-20-AQGO | 20 (40 μL) | 200 μL |
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| HDAC4-SNX18-20-AQGR | 20 (40 μL) | 200 μL |
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| HDAC4-SNX18-20-AQAQ | 20 (40 μL) | 200 μL |
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HDAC4 Gene Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
Gene Name: Histone Deacetylase 4
Chromosome: CHR2: 239969863 -240322643
Locus: 2q37.3
SNX18 Gene Summary
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Sorting Nexin 18
Chromosome: CHR5: 53813588 -53842416
Locus: 5q11.2
Gene Diseases
The HDAC4 SNX18 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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