HDAC4-SATB2 Fusion FISH Probe
The HDAC4-SATB2 Fusion FISH Probe is used to confirm a fusion of the HDAC4 and SATB2 genes. The fusion of the HDAC4 and SATB2 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HDAC4-SATB2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HDAC4-SATB2-20-RERE | 20 (40 μL) | 200 μL |
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| HDAC4-SATB2-20-REOR | 20 (40 μL) | 200 μL |
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| HDAC4-SATB2-20-REGO | 20 (40 μL) | 200 μL |
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| HDAC4-SATB2-20-REGR | 20 (40 μL) | 200 μL |
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| HDAC4-SATB2-20-REAQ | 20 (40 μL) | 200 μL |
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| HDAC4-SATB2-20-ORRE | 20 (40 μL) | 200 μL |
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| HDAC4-SATB2-20-OROR | 20 (40 μL) | 200 μL |
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| HDAC4-SATB2-20-ORGO | 20 (40 μL) | 200 μL |
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| HDAC4-SATB2-20-ORAQ | 20 (40 μL) | 200 μL |
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| HDAC4-SATB2-20-GORE | 20 (40 μL) | 200 μL |
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| HDAC4-SATB2-20-GOOR | 20 (40 μL) | 200 μL |
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| HDAC4-SATB2-20-GOGO | 20 (40 μL) | 200 μL |
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| HDAC4-SATB2-20-GOGR | 20 (40 μL) | 200 μL |
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| HDAC4-SATB2-20-GOAQ | 20 (40 μL) | 200 μL |
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| HDAC4-SATB2-20-GRRE | 20 (40 μL) | 200 μL |
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| HDAC4-SATB2-20-GROR | 20 (40 μL) | 200 μL |
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| HDAC4-SATB2-20-GRGO | 20 (40 μL) | 200 μL |
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| HDAC4-SATB2-20-GRGR | 20 (40 μL) | 200 μL |
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| HDAC4-SATB2-20-GRAQ | 20 (40 μL) | 200 μL |
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| HDAC4-SATB2-20-AQRE | 20 (40 μL) | 200 μL |
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| HDAC4-SATB2-20-AQOR | 20 (40 μL) | 200 μL |
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| HDAC4-SATB2-20-AQGO | 20 (40 μL) | 200 μL |
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| HDAC4-SATB2-20-AQGR | 20 (40 μL) | 200 μL |
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| HDAC4-SATB2-20-AQAQ | 20 (40 μL) | 200 μL |
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HDAC4 Gene Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
Gene Name: Histone Deacetylase 4
Chromosome: CHR2: 239969863 -240322643
Locus: 2q37.3
SATB2 Gene Summary
This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Feb 2010]
Gene Name: SATB Homeobox 2
Chromosome: CHR2: 200134222 -200335989
Locus: 2q33.1
Gene Diseases
The HDAC4 SATB2 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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