HDAC4-PDE11A Fusion FISH Probe
The HDAC4-PDE11A Fusion FISH Probe is used to confirm a fusion of the HDAC4 and PDE11A genes. The fusion of the HDAC4 and PDE11A genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HDAC4-PDE11A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HDAC4-PDE11A-20-RERE | 20 (40 μL) | 200 μL |
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| HDAC4-PDE11A-20-REOR | 20 (40 μL) | 200 μL |
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| HDAC4-PDE11A-20-REGO | 20 (40 μL) | 200 μL |
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| HDAC4-PDE11A-20-REGR | 20 (40 μL) | 200 μL |
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| HDAC4-PDE11A-20-REAQ | 20 (40 μL) | 200 μL |
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| HDAC4-PDE11A-20-ORRE | 20 (40 μL) | 200 μL |
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| HDAC4-PDE11A-20-OROR | 20 (40 μL) | 200 μL |
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| HDAC4-PDE11A-20-ORGO | 20 (40 μL) | 200 μL |
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| HDAC4-PDE11A-20-ORAQ | 20 (40 μL) | 200 μL |
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| HDAC4-PDE11A-20-GORE | 20 (40 μL) | 200 μL |
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| HDAC4-PDE11A-20-GOOR | 20 (40 μL) | 200 μL |
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| HDAC4-PDE11A-20-GOGO | 20 (40 μL) | 200 μL |
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| HDAC4-PDE11A-20-GOGR | 20 (40 μL) | 200 μL |
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| HDAC4-PDE11A-20-GOAQ | 20 (40 μL) | 200 μL |
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| HDAC4-PDE11A-20-GRRE | 20 (40 μL) | 200 μL |
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| HDAC4-PDE11A-20-GROR | 20 (40 μL) | 200 μL |
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| HDAC4-PDE11A-20-GRGO | 20 (40 μL) | 200 μL |
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| HDAC4-PDE11A-20-GRGR | 20 (40 μL) | 200 μL |
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| HDAC4-PDE11A-20-GRAQ | 20 (40 μL) | 200 μL |
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| HDAC4-PDE11A-20-AQRE | 20 (40 μL) | 200 μL |
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| HDAC4-PDE11A-20-AQOR | 20 (40 μL) | 200 μL |
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| HDAC4-PDE11A-20-AQGO | 20 (40 μL) | 200 μL |
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| HDAC4-PDE11A-20-AQGR | 20 (40 μL) | 200 μL |
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| HDAC4-PDE11A-20-AQAQ | 20 (40 μL) | 200 μL |
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HDAC4 Gene Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
Gene Name: Histone Deacetylase 4
Chromosome: CHR2: 239969863 -240322643
Locus: 2q37.3
PDE11A Gene Summary
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Phosphodiesterase 11A
Chromosome: CHR2: 178487976 -178973066
Locus: 2q31.2
Gene Diseases
The HDAC4 PDE11A Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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