HCFC1-EPHA5 Fusion FISH Probe
The HCFC1-EPHA5 Fusion FISH Probe is used to confirm a fusion of the HCFC1 and EPHA5 genes. The fusion of the HCFC1 and EPHA5 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HCFC1-EPHA5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HCFC1-EPHA5-20-RERE | 20 (40 μL) | 200 μL |
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| HCFC1-EPHA5-20-REOR | 20 (40 μL) | 200 μL |
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| HCFC1-EPHA5-20-REGO | 20 (40 μL) | 200 μL |
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| HCFC1-EPHA5-20-REGR | 20 (40 μL) | 200 μL |
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| HCFC1-EPHA5-20-REAQ | 20 (40 μL) | 200 μL |
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| HCFC1-EPHA5-20-ORRE | 20 (40 μL) | 200 μL |
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| HCFC1-EPHA5-20-OROR | 20 (40 μL) | 200 μL |
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| HCFC1-EPHA5-20-ORGO | 20 (40 μL) | 200 μL |
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| HCFC1-EPHA5-20-ORAQ | 20 (40 μL) | 200 μL |
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| HCFC1-EPHA5-20-GORE | 20 (40 μL) | 200 μL |
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| HCFC1-EPHA5-20-GOOR | 20 (40 μL) | 200 μL |
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| HCFC1-EPHA5-20-GOGO | 20 (40 μL) | 200 μL |
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| HCFC1-EPHA5-20-GOGR | 20 (40 μL) | 200 μL |
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| HCFC1-EPHA5-20-GOAQ | 20 (40 μL) | 200 μL |
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| HCFC1-EPHA5-20-GRRE | 20 (40 μL) | 200 μL |
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| HCFC1-EPHA5-20-GROR | 20 (40 μL) | 200 μL |
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| HCFC1-EPHA5-20-GRGO | 20 (40 μL) | 200 μL |
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| HCFC1-EPHA5-20-GRGR | 20 (40 μL) | 200 μL |
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| HCFC1-EPHA5-20-GRAQ | 20 (40 μL) | 200 μL |
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| HCFC1-EPHA5-20-AQRE | 20 (40 μL) | 200 μL |
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| HCFC1-EPHA5-20-AQOR | 20 (40 μL) | 200 μL |
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| HCFC1-EPHA5-20-AQGO | 20 (40 μL) | 200 μL |
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| HCFC1-EPHA5-20-AQGR | 20 (40 μL) | 200 μL |
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| HCFC1-EPHA5-20-AQAQ | 20 (40 μL) | 200 μL |
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EPHA5 Gene Summary
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]
Gene Name: EPH Receptor A5
Chromosome: CHR4: 66185280 -66535653
Locus: 4q13.1-q13.2
HCFC1 Gene Summary
This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Gene Name: Host Cell Factor C1
Chromosome: CHRX: 153213007 -153236819
Locus: Xq28
Gene Diseases
The HCFC1 EPHA5 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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