HBG2-TRIM22 Fusion FISH Probe
The HBG2-TRIM22 Fusion FISH Probe is used to confirm a fusion of the HBG2 and TRIM22 genes. The fusion of the HBG2 and TRIM22 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HBG2-TRIM22-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HBG2-TRIM22-20-RERE | 20 (40 μL) | 200 μL |
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| HBG2-TRIM22-20-REOR | 20 (40 μL) | 200 μL |
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| HBG2-TRIM22-20-REGO | 20 (40 μL) | 200 μL |
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| HBG2-TRIM22-20-REGR | 20 (40 μL) | 200 μL |
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| HBG2-TRIM22-20-REAQ | 20 (40 μL) | 200 μL |
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| HBG2-TRIM22-20-ORRE | 20 (40 μL) | 200 μL |
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| HBG2-TRIM22-20-OROR | 20 (40 μL) | 200 μL |
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| HBG2-TRIM22-20-ORGO | 20 (40 μL) | 200 μL |
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| HBG2-TRIM22-20-ORAQ | 20 (40 μL) | 200 μL |
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| HBG2-TRIM22-20-GORE | 20 (40 μL) | 200 μL |
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| HBG2-TRIM22-20-GOOR | 20 (40 μL) | 200 μL |
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| HBG2-TRIM22-20-GOGO | 20 (40 μL) | 200 μL |
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| HBG2-TRIM22-20-GOGR | 20 (40 μL) | 200 μL |
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| HBG2-TRIM22-20-GOAQ | 20 (40 μL) | 200 μL |
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| HBG2-TRIM22-20-GRRE | 20 (40 μL) | 200 μL |
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| HBG2-TRIM22-20-GROR | 20 (40 μL) | 200 μL |
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| HBG2-TRIM22-20-GRGO | 20 (40 μL) | 200 μL |
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| HBG2-TRIM22-20-GRGR | 20 (40 μL) | 200 μL |
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| HBG2-TRIM22-20-GRAQ | 20 (40 μL) | 200 μL |
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| HBG2-TRIM22-20-AQRE | 20 (40 μL) | 200 μL |
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| HBG2-TRIM22-20-AQOR | 20 (40 μL) | 200 μL |
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| HBG2-TRIM22-20-AQGO | 20 (40 μL) | 200 μL |
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| HBG2-TRIM22-20-AQGR | 20 (40 μL) | 200 μL |
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| HBG2-TRIM22-20-AQAQ | 20 (40 μL) | 200 μL |
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HBG2 Gene Summary
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'- epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]
Gene Name: Hemoglobin Subunit Gamma 2
Chromosome: CHR11: 5274420 -5276011
Locus: 11p15.4
TRIM22 Gene Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Gene Name: Tripartite Motif Containing 22
Chromosome: CHR11: 5710816 -5732093
Locus: 11p15.4
Gene Diseases
The HBG2 TRIM22 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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