HAS2-HHLA1 Fusion FISH Probe
The HAS2-HHLA1 Fusion FISH Probe is used to confirm a fusion of the HAS2 and HHLA1 genes. The fusion of the HAS2 and HHLA1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HAS2-HHLA1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HAS2-HHLA1-20-RERE | 20 (40 μL) | 200 μL |
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| HAS2-HHLA1-20-REOR | 20 (40 μL) | 200 μL |
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| HAS2-HHLA1-20-REGO | 20 (40 μL) | 200 μL |
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| HAS2-HHLA1-20-REGR | 20 (40 μL) | 200 μL |
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| HAS2-HHLA1-20-REAQ | 20 (40 μL) | 200 μL |
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| HAS2-HHLA1-20-ORRE | 20 (40 μL) | 200 μL |
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| HAS2-HHLA1-20-OROR | 20 (40 μL) | 200 μL |
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| HAS2-HHLA1-20-ORGO | 20 (40 μL) | 200 μL |
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| HAS2-HHLA1-20-ORAQ | 20 (40 μL) | 200 μL |
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| HAS2-HHLA1-20-GORE | 20 (40 μL) | 200 μL |
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| HAS2-HHLA1-20-GOOR | 20 (40 μL) | 200 μL |
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| HAS2-HHLA1-20-GOGO | 20 (40 μL) | 200 μL |
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| HAS2-HHLA1-20-GOGR | 20 (40 μL) | 200 μL |
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| HAS2-HHLA1-20-GOAQ | 20 (40 μL) | 200 μL |
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| HAS2-HHLA1-20-GRRE | 20 (40 μL) | 200 μL |
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| HAS2-HHLA1-20-GROR | 20 (40 μL) | 200 μL |
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| HAS2-HHLA1-20-GRGO | 20 (40 μL) | 200 μL |
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| HAS2-HHLA1-20-GRGR | 20 (40 μL) | 200 μL |
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| HAS2-HHLA1-20-GRAQ | 20 (40 μL) | 200 μL |
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| HAS2-HHLA1-20-AQRE | 20 (40 μL) | 200 μL |
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| HAS2-HHLA1-20-AQOR | 20 (40 μL) | 200 μL |
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| HAS2-HHLA1-20-AQGO | 20 (40 μL) | 200 μL |
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| HAS2-HHLA1-20-AQGR | 20 (40 μL) | 200 μL |
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| HAS2-HHLA1-20-AQAQ | 20 (40 μL) | 200 μL |
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HAS2 Gene Summary
Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1. [provided by RefSeq, Jul 2008]
Gene Name: Hyaluronan Synthase 2
Chromosome: CHR8: 122625270 -122653630
Locus: 8q24.13
HHLA1 Gene Summary
The HERV-H LTR-associating 1 (HHLA1) gene is located on chr8 :133073732-133117512 at 8q24.22.
Gene Name: HERV-H LTR-associating 1
Chromosome: CHR8: 133073732 -133117512
Locus: 8q24.22
Gene Diseases
The HAS2 HHLA1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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