HARS-TMCO6 Fusion FISH Probe
The HARS-TMCO6 Fusion FISH Probe is used to confirm a fusion of the HARS and TMCO6 genes. The fusion of the HARS and TMCO6 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HARS-TMCO6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HARS-TMCO6-20-RERE | 20 (40 μL) | 200 μL |
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| HARS-TMCO6-20-REOR | 20 (40 μL) | 200 μL |
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| HARS-TMCO6-20-REGO | 20 (40 μL) | 200 μL |
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| HARS-TMCO6-20-REGR | 20 (40 μL) | 200 μL |
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| HARS-TMCO6-20-REAQ | 20 (40 μL) | 200 μL |
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| HARS-TMCO6-20-ORRE | 20 (40 μL) | 200 μL |
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| HARS-TMCO6-20-OROR | 20 (40 μL) | 200 μL |
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| HARS-TMCO6-20-ORGO | 20 (40 μL) | 200 μL |
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| HARS-TMCO6-20-ORAQ | 20 (40 μL) | 200 μL |
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| HARS-TMCO6-20-GORE | 20 (40 μL) | 200 μL |
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| HARS-TMCO6-20-GOOR | 20 (40 μL) | 200 μL |
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| HARS-TMCO6-20-GOGO | 20 (40 μL) | 200 μL |
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| HARS-TMCO6-20-GOGR | 20 (40 μL) | 200 μL |
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| HARS-TMCO6-20-GOAQ | 20 (40 μL) | 200 μL |
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| HARS-TMCO6-20-GRRE | 20 (40 μL) | 200 μL |
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| HARS-TMCO6-20-GROR | 20 (40 μL) | 200 μL |
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| HARS-TMCO6-20-GRGO | 20 (40 μL) | 200 μL |
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| HARS-TMCO6-20-GRGR | 20 (40 μL) | 200 μL |
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| HARS-TMCO6-20-GRAQ | 20 (40 μL) | 200 μL |
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| HARS-TMCO6-20-AQRE | 20 (40 μL) | 200 μL |
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| HARS-TMCO6-20-AQOR | 20 (40 μL) | 200 μL |
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| HARS-TMCO6-20-AQGO | 20 (40 μL) | 200 μL |
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| HARS-TMCO6-20-AQGR | 20 (40 μL) | 200 μL |
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| HARS-TMCO6-20-AQAQ | 20 (40 μL) | 200 μL |
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HARS Gene Summary
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Name: Histidyl-tRNA Synthetase
Chromosome: CHR5: 140053489 -140070971
Locus: 5q31.3
TMCO6 Gene Summary
The Transmembrane And Coiled-coil Domains 6 (TMCO6) gene is located on chr5 :140019011-140024989 at 5q31.3.
Gene Name: Transmembrane And Coiled-coil Domains 6
Chromosome: CHR5: 140019011 -140024989
Locus: 5q31.3
Gene Diseases
The HARS TMCO6 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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