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HARS-FAM53C Fusion FISH Probe

The HARS-FAM53C Fusion FISH Probe is used to confirm a fusion of the HARS and FAM53C genes. The fusion of the HARS and FAM53C genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
HARS-FAM53C-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
HARS-FAM53C-20-RERE 20 (40 μL) 200 μL
HARS-FAM53C-20-REOR 20 (40 μL) 200 μL
HARS-FAM53C-20-REGO 20 (40 μL) 200 μL
HARS-FAM53C-20-REGR 20 (40 μL) 200 μL
HARS-FAM53C-20-REAQ 20 (40 μL) 200 μL
HARS-FAM53C-20-ORRE 20 (40 μL) 200 μL
HARS-FAM53C-20-OROR 20 (40 μL) 200 μL
HARS-FAM53C-20-ORGO 20 (40 μL) 200 μL
HARS-FAM53C-20-ORAQ 20 (40 μL) 200 μL
HARS-FAM53C-20-GORE 20 (40 μL) 200 μL
HARS-FAM53C-20-GOOR 20 (40 μL) 200 μL
HARS-FAM53C-20-GOGO 20 (40 μL) 200 μL
HARS-FAM53C-20-GOGR 20 (40 μL) 200 μL
HARS-FAM53C-20-GOAQ 20 (40 μL) 200 μL
HARS-FAM53C-20-GRRE 20 (40 μL) 200 μL
HARS-FAM53C-20-GROR 20 (40 μL) 200 μL
HARS-FAM53C-20-GRGO 20 (40 μL) 200 μL
HARS-FAM53C-20-GRGR 20 (40 μL) 200 μL
HARS-FAM53C-20-GRAQ 20 (40 μL) 200 μL
HARS-FAM53C-20-AQRE 20 (40 μL) 200 μL
HARS-FAM53C-20-AQOR 20 (40 μL) 200 μL
HARS-FAM53C-20-AQGO 20 (40 μL) 200 μL
HARS-FAM53C-20-AQGR 20 (40 μL) 200 μL
HARS-FAM53C-20-AQAQ 20 (40 μL) 200 μL

HARS Gene Summary

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Gene Name: Histidyl-tRNA Synthetase

Chromosome: CHR5: 140053489 -140070971

Locus: 5q31.3

FAM53C Gene Summary

The protein encoded by this gene belongs to the FAM53 protein family. FAM53 protein family members bind to a transcriptional regulator that modulates cell proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

Gene Name: Family With Sequence Similarity 53 Member C

Chromosome: CHR5: 137673223 -137685418

Locus: 5q31.2

Gene Diseases

The HARS FAM53C Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.