H3F3B-CCT5 Fusion FISH Probe
The H3F3B-CCT5 Fusion FISH Probe is used to confirm a fusion of the H3F3B and CCT5 genes. The fusion of the H3F3B and CCT5 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| H3F3B-CCT5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| H3F3B-CCT5-20-RERE | 20 (40 μL) | 200 μL |
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| H3F3B-CCT5-20-REOR | 20 (40 μL) | 200 μL |
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| H3F3B-CCT5-20-REGO | 20 (40 μL) | 200 μL |
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| H3F3B-CCT5-20-REGR | 20 (40 μL) | 200 μL |
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| H3F3B-CCT5-20-REAQ | 20 (40 μL) | 200 μL |
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| H3F3B-CCT5-20-ORRE | 20 (40 μL) | 200 μL |
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| H3F3B-CCT5-20-OROR | 20 (40 μL) | 200 μL |
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| H3F3B-CCT5-20-ORGO | 20 (40 μL) | 200 μL |
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| H3F3B-CCT5-20-ORAQ | 20 (40 μL) | 200 μL |
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| H3F3B-CCT5-20-GORE | 20 (40 μL) | 200 μL |
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| H3F3B-CCT5-20-GOOR | 20 (40 μL) | 200 μL |
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| H3F3B-CCT5-20-GOGO | 20 (40 μL) | 200 μL |
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| H3F3B-CCT5-20-GOGR | 20 (40 μL) | 200 μL |
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| H3F3B-CCT5-20-GOAQ | 20 (40 μL) | 200 μL |
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| H3F3B-CCT5-20-GRRE | 20 (40 μL) | 200 μL |
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| H3F3B-CCT5-20-GROR | 20 (40 μL) | 200 μL |
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| H3F3B-CCT5-20-GRGO | 20 (40 μL) | 200 μL |
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| H3F3B-CCT5-20-GRGR | 20 (40 μL) | 200 μL |
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| H3F3B-CCT5-20-GRAQ | 20 (40 μL) | 200 μL |
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| H3F3B-CCT5-20-AQRE | 20 (40 μL) | 200 μL |
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| H3F3B-CCT5-20-AQOR | 20 (40 μL) | 200 μL |
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| H3F3B-CCT5-20-AQGO | 20 (40 μL) | 200 μL |
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| H3F3B-CCT5-20-AQGR | 20 (40 μL) | 200 μL |
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| H3F3B-CCT5-20-AQAQ | 20 (40 μL) | 200 μL |
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H3F3B Gene Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded by this gene is a replication-independent histone that is a member of the histone H3 family. Pseudogenes of this gene have been identified on the X chromosome, and on chromosomes 5, 13 and 17. [provided by RefSeq, Oct 2015]
Gene Name: H3 Histone Family Member 3B
Chromosome: CHR17: 73772514 -73775860
Locus: 17q25.1
CCT5 Gene Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]
Gene Name: Chaperonin Containing TCP1 Subunit 5
Chromosome: CHR5: 10250281 -10266501
Locus: 5p15.2
Gene Diseases
The H3F3B CCT5 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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