H2AFY-CNOT6 Fusion FISH Probe
The H2AFY-CNOT6 Fusion FISH Probe is used to confirm a fusion of the H2AFY and CNOT6 genes. The fusion of the H2AFY and CNOT6 genes has been associated with Breast Invasive Carcinoma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| H2AFY-CNOT6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| H2AFY-CNOT6-20-RERE | 20 (40 μL) | 200 μL |
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| H2AFY-CNOT6-20-REOR | 20 (40 μL) | 200 μL |
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| H2AFY-CNOT6-20-REGO | 20 (40 μL) | 200 μL |
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| H2AFY-CNOT6-20-REGR | 20 (40 μL) | 200 μL |
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| H2AFY-CNOT6-20-REAQ | 20 (40 μL) | 200 μL |
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| H2AFY-CNOT6-20-ORRE | 20 (40 μL) | 200 μL |
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| H2AFY-CNOT6-20-OROR | 20 (40 μL) | 200 μL |
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| H2AFY-CNOT6-20-ORGO | 20 (40 μL) | 200 μL |
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| H2AFY-CNOT6-20-ORAQ | 20 (40 μL) | 200 μL |
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| H2AFY-CNOT6-20-GORE | 20 (40 μL) | 200 μL |
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| H2AFY-CNOT6-20-GOOR | 20 (40 μL) | 200 μL |
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| H2AFY-CNOT6-20-GOGO | 20 (40 μL) | 200 μL |
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| H2AFY-CNOT6-20-GOGR | 20 (40 μL) | 200 μL |
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| H2AFY-CNOT6-20-GOAQ | 20 (40 μL) | 200 μL |
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| H2AFY-CNOT6-20-GRRE | 20 (40 μL) | 200 μL |
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| H2AFY-CNOT6-20-GROR | 20 (40 μL) | 200 μL |
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| H2AFY-CNOT6-20-GRGO | 20 (40 μL) | 200 μL |
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| H2AFY-CNOT6-20-GRGR | 20 (40 μL) | 200 μL |
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| H2AFY-CNOT6-20-GRAQ | 20 (40 μL) | 200 μL |
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| H2AFY-CNOT6-20-AQRE | 20 (40 μL) | 200 μL |
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| H2AFY-CNOT6-20-AQOR | 20 (40 μL) | 200 μL |
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| H2AFY-CNOT6-20-AQGO | 20 (40 μL) | 200 μL |
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| H2AFY-CNOT6-20-AQGR | 20 (40 μL) | 200 μL |
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| H2AFY-CNOT6-20-AQAQ | 20 (40 μL) | 200 μL |
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H2AFY Gene Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]
Gene Name: H2A Histone Family Member Y
Chromosome: CHR5: 134670070 -134735577
Locus: 5q31.1
CNOT6 Gene Summary
This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014]
Gene Name: CCR4-NOT Transcription Complex Subunit 6
Chromosome: CHR5: 179921416 -180005353
Locus: 5q35.3
Gene Diseases
The H2AFY CNOT6 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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