H2AFV-CDC45 Fusion FISH Probe
The H2AFV-CDC45 Fusion FISH Probe is used to confirm a fusion of the H2AFV and CDC45 genes. The fusion of the H2AFV and CDC45 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| H2AFV-CDC45-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| H2AFV-CDC45-20-RERE | 20 (40 μL) | 200 μL |
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| H2AFV-CDC45-20-REOR | 20 (40 μL) | 200 μL |
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| H2AFV-CDC45-20-REGO | 20 (40 μL) | 200 μL |
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| H2AFV-CDC45-20-REGR | 20 (40 μL) | 200 μL |
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| H2AFV-CDC45-20-REAQ | 20 (40 μL) | 200 μL |
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| H2AFV-CDC45-20-ORRE | 20 (40 μL) | 200 μL |
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| H2AFV-CDC45-20-OROR | 20 (40 μL) | 200 μL |
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| H2AFV-CDC45-20-ORGO | 20 (40 μL) | 200 μL |
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| H2AFV-CDC45-20-ORAQ | 20 (40 μL) | 200 μL |
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| H2AFV-CDC45-20-GORE | 20 (40 μL) | 200 μL |
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| H2AFV-CDC45-20-GOOR | 20 (40 μL) | 200 μL |
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| H2AFV-CDC45-20-GOGO | 20 (40 μL) | 200 μL |
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| H2AFV-CDC45-20-GOGR | 20 (40 μL) | 200 μL |
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| H2AFV-CDC45-20-GOAQ | 20 (40 μL) | 200 μL |
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| H2AFV-CDC45-20-GRRE | 20 (40 μL) | 200 μL |
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| H2AFV-CDC45-20-GROR | 20 (40 μL) | 200 μL |
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| H2AFV-CDC45-20-GRGO | 20 (40 μL) | 200 μL |
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| H2AFV-CDC45-20-GRGR | 20 (40 μL) | 200 μL |
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| H2AFV-CDC45-20-GRAQ | 20 (40 μL) | 200 μL |
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| H2AFV-CDC45-20-AQRE | 20 (40 μL) | 200 μL |
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| H2AFV-CDC45-20-AQOR | 20 (40 μL) | 200 μL |
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| H2AFV-CDC45-20-AQGO | 20 (40 μL) | 200 μL |
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| H2AFV-CDC45-20-AQGR | 20 (40 μL) | 200 μL |
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| H2AFV-CDC45-20-AQAQ | 20 (40 μL) | 200 μL |
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CDC45 Gene Summary
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Name: Cell Division Cycle 45
Chromosome: CHR22: 19467413 -19508135
Locus: 22q11.21
H2AFV Gene Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. Several transcript variants encoding different isoforms, have been identified for this gene. [provided by RefSeq, Oct 2015]
Gene Name: H2A Histone Family Member V
Chromosome: CHR7: 44866487 -44887725
Locus: 7p13
Gene Diseases
The H2AFV CDC45 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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