H2AFJ-ARFGEF2 Fusion FISH Probe
The H2AFJ-ARFGEF2 Fusion FISH Probe is used to confirm a fusion of the H2AFJ and ARFGEF2 genes. The fusion of the H2AFJ and ARFGEF2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| H2AFJ-ARFGEF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| H2AFJ-ARFGEF2-20-RERE | 20 (40 μL) | 200 μL |
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| H2AFJ-ARFGEF2-20-REOR | 20 (40 μL) | 200 μL |
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| H2AFJ-ARFGEF2-20-REGO | 20 (40 μL) | 200 μL |
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| H2AFJ-ARFGEF2-20-REGR | 20 (40 μL) | 200 μL |
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| H2AFJ-ARFGEF2-20-REAQ | 20 (40 μL) | 200 μL |
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| H2AFJ-ARFGEF2-20-ORRE | 20 (40 μL) | 200 μL |
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| H2AFJ-ARFGEF2-20-OROR | 20 (40 μL) | 200 μL |
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| H2AFJ-ARFGEF2-20-ORGO | 20 (40 μL) | 200 μL |
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| H2AFJ-ARFGEF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| H2AFJ-ARFGEF2-20-GORE | 20 (40 μL) | 200 μL |
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| H2AFJ-ARFGEF2-20-GOOR | 20 (40 μL) | 200 μL |
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| H2AFJ-ARFGEF2-20-GOGO | 20 (40 μL) | 200 μL |
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| H2AFJ-ARFGEF2-20-GOGR | 20 (40 μL) | 200 μL |
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| H2AFJ-ARFGEF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| H2AFJ-ARFGEF2-20-GRRE | 20 (40 μL) | 200 μL |
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| H2AFJ-ARFGEF2-20-GROR | 20 (40 μL) | 200 μL |
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| H2AFJ-ARFGEF2-20-GRGO | 20 (40 μL) | 200 μL |
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| H2AFJ-ARFGEF2-20-GRGR | 20 (40 μL) | 200 μL |
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| H2AFJ-ARFGEF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| H2AFJ-ARFGEF2-20-AQRE | 20 (40 μL) | 200 μL |
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| H2AFJ-ARFGEF2-20-AQOR | 20 (40 μL) | 200 μL |
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| H2AFJ-ARFGEF2-20-AQGO | 20 (40 μL) | 200 μL |
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| H2AFJ-ARFGEF2-20-AQGR | 20 (40 μL) | 200 μL |
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| H2AFJ-ARFGEF2-20-AQAQ | 20 (40 μL) | 200 μL |
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ARFGEF2 Gene Summary
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
Gene Name: ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2
Chromosome: CHR20: 47538274 -47653230
Locus: 20q13.13
H2AFJ Gene Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is located on chromosome 12 and encodes a replication-independent histone that is a variant H2A histone. The protein is divergent at the C-terminus compared to the consensus H2A histone family member. This gene also encodes an antimicrobial peptide with antibacterial and antifungal activity.[provided by RefSeq, Oct 2015]
Gene Name: H2A Histone Family Member J
Chromosome: CHR12: 14927269 -14930936
Locus: 12p12.3
Gene Diseases
The H2AFJ ARFGEF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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