GZMM-HNRNPM Fusion FISH Probe
The GZMM-HNRNPM Fusion FISH Probe is used to confirm a fusion of the GZMM and HNRNPM genes. The fusion of the GZMM and HNRNPM genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GZMM-HNRNPM-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GZMM-HNRNPM-20-RERE | 20 (40 μL) | 200 μL |
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| GZMM-HNRNPM-20-REOR | 20 (40 μL) | 200 μL |
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| GZMM-HNRNPM-20-REGO | 20 (40 μL) | 200 μL |
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| GZMM-HNRNPM-20-REGR | 20 (40 μL) | 200 μL |
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| GZMM-HNRNPM-20-REAQ | 20 (40 μL) | 200 μL |
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| GZMM-HNRNPM-20-ORRE | 20 (40 μL) | 200 μL |
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| GZMM-HNRNPM-20-OROR | 20 (40 μL) | 200 μL |
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| GZMM-HNRNPM-20-ORGO | 20 (40 μL) | 200 μL |
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| GZMM-HNRNPM-20-ORAQ | 20 (40 μL) | 200 μL |
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| GZMM-HNRNPM-20-GORE | 20 (40 μL) | 200 μL |
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| GZMM-HNRNPM-20-GOOR | 20 (40 μL) | 200 μL |
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| GZMM-HNRNPM-20-GOGO | 20 (40 μL) | 200 μL |
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| GZMM-HNRNPM-20-GOGR | 20 (40 μL) | 200 μL |
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| GZMM-HNRNPM-20-GOAQ | 20 (40 μL) | 200 μL |
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| GZMM-HNRNPM-20-GRRE | 20 (40 μL) | 200 μL |
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| GZMM-HNRNPM-20-GROR | 20 (40 μL) | 200 μL |
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| GZMM-HNRNPM-20-GRGO | 20 (40 μL) | 200 μL |
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| GZMM-HNRNPM-20-GRGR | 20 (40 μL) | 200 μL |
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| GZMM-HNRNPM-20-GRAQ | 20 (40 μL) | 200 μL |
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| GZMM-HNRNPM-20-AQRE | 20 (40 μL) | 200 μL |
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| GZMM-HNRNPM-20-AQOR | 20 (40 μL) | 200 μL |
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| GZMM-HNRNPM-20-AQGO | 20 (40 μL) | 200 μL |
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| GZMM-HNRNPM-20-AQGR | 20 (40 μL) | 200 μL |
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| GZMM-HNRNPM-20-AQAQ | 20 (40 μL) | 200 μL |
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GZMM Gene Summary
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Name: Granzyme M
Chromosome: CHR19: 544026 -549919
Locus: 19p13.3
HNRNPM Gene Summary
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Name: Heterogeneous Nuclear Ribonucleoprotein M
Chromosome: CHR19: 8509802 -8554002
Locus: 19p13.2
Gene Diseases
The GZMM HNRNPM Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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