GXYLT2-NEK3 Fusion FISH Probe
The GXYLT2-NEK3 Fusion FISH Probe is used to confirm a fusion of the GXYLT2 and NEK3 genes. The fusion of the GXYLT2 and NEK3 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GXYLT2-NEK3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GXYLT2-NEK3-20-RERE | 20 (40 μL) | 200 μL |
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| GXYLT2-NEK3-20-REOR | 20 (40 μL) | 200 μL |
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| GXYLT2-NEK3-20-REGO | 20 (40 μL) | 200 μL |
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| GXYLT2-NEK3-20-REGR | 20 (40 μL) | 200 μL |
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| GXYLT2-NEK3-20-REAQ | 20 (40 μL) | 200 μL |
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| GXYLT2-NEK3-20-ORRE | 20 (40 μL) | 200 μL |
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| GXYLT2-NEK3-20-OROR | 20 (40 μL) | 200 μL |
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| GXYLT2-NEK3-20-ORGO | 20 (40 μL) | 200 μL |
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| GXYLT2-NEK3-20-ORAQ | 20 (40 μL) | 200 μL |
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| GXYLT2-NEK3-20-GORE | 20 (40 μL) | 200 μL |
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| GXYLT2-NEK3-20-GOOR | 20 (40 μL) | 200 μL |
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| GXYLT2-NEK3-20-GOGO | 20 (40 μL) | 200 μL |
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| GXYLT2-NEK3-20-GOGR | 20 (40 μL) | 200 μL |
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| GXYLT2-NEK3-20-GOAQ | 20 (40 μL) | 200 μL |
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| GXYLT2-NEK3-20-GRRE | 20 (40 μL) | 200 μL |
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| GXYLT2-NEK3-20-GROR | 20 (40 μL) | 200 μL |
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| GXYLT2-NEK3-20-GRGO | 20 (40 μL) | 200 μL |
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| GXYLT2-NEK3-20-GRGR | 20 (40 μL) | 200 μL |
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| GXYLT2-NEK3-20-GRAQ | 20 (40 μL) | 200 μL |
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| GXYLT2-NEK3-20-AQRE | 20 (40 μL) | 200 μL |
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| GXYLT2-NEK3-20-AQOR | 20 (40 μL) | 200 μL |
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| GXYLT2-NEK3-20-AQGO | 20 (40 μL) | 200 μL |
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| GXYLT2-NEK3-20-AQGR | 20 (40 μL) | 200 μL |
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| GXYLT2-NEK3-20-AQAQ | 20 (40 μL) | 200 μL |
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NEK3 Gene Summary
This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
Gene Name: NIMA Related Kinase 3
Chromosome: CHR13: 52706778 -52733996
Locus: 13q14.3
GXYLT2 Gene Summary
The protein encoded by this gene is a xylosyltransferase that elongates O-linked glucose bound to epidermal growth factor (EGF) repeats. The encoded protein catalyzes the addition of xylose to the O-glucose-modified residues of EGF repeats of Notch proteins. [provided by RefSeq, Sep 2016]
Gene Name: Glucoside Xylosyltransferase 2
Chromosome: CHR3: 72937384 -73024522
Locus: 3p13
Gene Diseases
The GXYLT2 NEK3 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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