GUCY1B3-PTPRG Fusion FISH Probe
The GUCY1B3-PTPRG Fusion FISH Probe is used to confirm a fusion of the GUCY1B3 and PTPRG genes. The fusion of the GUCY1B3 and PTPRG genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GUCY1B3-PTPRG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GUCY1B3-PTPRG-20-RERE | 20 (40 μL) | 200 μL |
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| GUCY1B3-PTPRG-20-REOR | 20 (40 μL) | 200 μL |
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| GUCY1B3-PTPRG-20-REGO | 20 (40 μL) | 200 μL |
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| GUCY1B3-PTPRG-20-REGR | 20 (40 μL) | 200 μL |
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| GUCY1B3-PTPRG-20-REAQ | 20 (40 μL) | 200 μL |
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| GUCY1B3-PTPRG-20-ORRE | 20 (40 μL) | 200 μL |
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| GUCY1B3-PTPRG-20-OROR | 20 (40 μL) | 200 μL |
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| GUCY1B3-PTPRG-20-ORGO | 20 (40 μL) | 200 μL |
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| GUCY1B3-PTPRG-20-ORAQ | 20 (40 μL) | 200 μL |
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| GUCY1B3-PTPRG-20-GORE | 20 (40 μL) | 200 μL |
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| GUCY1B3-PTPRG-20-GOOR | 20 (40 μL) | 200 μL |
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| GUCY1B3-PTPRG-20-GOGO | 20 (40 μL) | 200 μL |
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| GUCY1B3-PTPRG-20-GOGR | 20 (40 μL) | 200 μL |
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| GUCY1B3-PTPRG-20-GOAQ | 20 (40 μL) | 200 μL |
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| GUCY1B3-PTPRG-20-GRRE | 20 (40 μL) | 200 μL |
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| GUCY1B3-PTPRG-20-GROR | 20 (40 μL) | 200 μL |
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| GUCY1B3-PTPRG-20-GRGO | 20 (40 μL) | 200 μL |
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| GUCY1B3-PTPRG-20-GRGR | 20 (40 μL) | 200 μL |
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| GUCY1B3-PTPRG-20-GRAQ | 20 (40 μL) | 200 μL |
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| GUCY1B3-PTPRG-20-AQRE | 20 (40 μL) | 200 μL |
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| GUCY1B3-PTPRG-20-AQOR | 20 (40 μL) | 200 μL |
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| GUCY1B3-PTPRG-20-AQGO | 20 (40 μL) | 200 μL |
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| GUCY1B3-PTPRG-20-AQGR | 20 (40 μL) | 200 μL |
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| GUCY1B3-PTPRG-20-AQAQ | 20 (40 μL) | 200 μL |
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GUCY1B3 Gene Summary
This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: Guanylate Cyclase 1 Soluble Subunit Beta
Chromosome: CHR4: 156680125 -156728783
Locus: 4q32.1
PTPRG Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type G
Chromosome: CHR3: 61547242 -62280573
Locus: 3p14.2
Gene Diseases
The GUCY1B3 PTPRG Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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