GTPBP2-POLH Fusion FISH Probe
The GTPBP2-POLH Fusion FISH Probe is used to confirm a fusion of the GTPBP2 and POLH genes. The fusion of the GTPBP2 and POLH genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GTPBP2-POLH-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GTPBP2-POLH-20-RERE | 20 (40 μL) | 200 μL |
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| GTPBP2-POLH-20-REOR | 20 (40 μL) | 200 μL |
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| GTPBP2-POLH-20-REGO | 20 (40 μL) | 200 μL |
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| GTPBP2-POLH-20-REGR | 20 (40 μL) | 200 μL |
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| GTPBP2-POLH-20-REAQ | 20 (40 μL) | 200 μL |
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| GTPBP2-POLH-20-ORRE | 20 (40 μL) | 200 μL |
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| GTPBP2-POLH-20-OROR | 20 (40 μL) | 200 μL |
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| GTPBP2-POLH-20-ORGO | 20 (40 μL) | 200 μL |
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| GTPBP2-POLH-20-ORAQ | 20 (40 μL) | 200 μL |
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| GTPBP2-POLH-20-GORE | 20 (40 μL) | 200 μL |
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| GTPBP2-POLH-20-GOOR | 20 (40 μL) | 200 μL |
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| GTPBP2-POLH-20-GOGO | 20 (40 μL) | 200 μL |
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| GTPBP2-POLH-20-GOGR | 20 (40 μL) | 200 μL |
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| GTPBP2-POLH-20-GOAQ | 20 (40 μL) | 200 μL |
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| GTPBP2-POLH-20-GRRE | 20 (40 μL) | 200 μL |
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| GTPBP2-POLH-20-GROR | 20 (40 μL) | 200 μL |
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| GTPBP2-POLH-20-GRGO | 20 (40 μL) | 200 μL |
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| GTPBP2-POLH-20-GRGR | 20 (40 μL) | 200 μL |
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| GTPBP2-POLH-20-GRAQ | 20 (40 μL) | 200 μL |
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| GTPBP2-POLH-20-AQRE | 20 (40 μL) | 200 μL |
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| GTPBP2-POLH-20-AQOR | 20 (40 μL) | 200 μL |
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| GTPBP2-POLH-20-AQGO | 20 (40 μL) | 200 μL |
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| GTPBP2-POLH-20-AQGR | 20 (40 μL) | 200 μL |
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| GTPBP2-POLH-20-AQAQ | 20 (40 μL) | 200 μL |
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POLH Gene Summary
This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Gene Name: DNA Polymerase Eta
Chromosome: CHR6: 43543877 -43588260
Locus: 6p21.1
GTPBP2 Gene Summary
GTP-binding proteins, or G proteins, constitute a superfamily capable of binding GTP or GDP. G proteins are activated by binding GTP and are inactivated by hydrolyzing GTP to GDP. This general mechanism enables G proteins to perform a wide range of biologic activities.[supplied by OMIM, Jan 2003]
Gene Name: GTP Binding Protein 2
Chromosome: CHR6: 43588217 -43596936
Locus: 6p21.1
Gene Diseases
The GTPBP2 POLH Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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