GTF2IRD1-ALK Fusion FISH Probe
The GTF2IRD1-ALK Fusion FISH Probe is used to confirm a fusion of the GTF2IRD1 and ALK genes. The fusion of the GTF2IRD1 and ALK genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GTF2IRD1-ALK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GTF2IRD1-ALK-20-RERE | 20 (40 μL) | 200 μL |
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| GTF2IRD1-ALK-20-REOR | 20 (40 μL) | 200 μL |
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| GTF2IRD1-ALK-20-REGO | 20 (40 μL) | 200 μL |
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| GTF2IRD1-ALK-20-REGR | 20 (40 μL) | 200 μL |
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| GTF2IRD1-ALK-20-REAQ | 20 (40 μL) | 200 μL |
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| GTF2IRD1-ALK-20-ORRE | 20 (40 μL) | 200 μL |
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| GTF2IRD1-ALK-20-OROR | 20 (40 μL) | 200 μL |
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| GTF2IRD1-ALK-20-ORGO | 20 (40 μL) | 200 μL |
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| GTF2IRD1-ALK-20-ORAQ | 20 (40 μL) | 200 μL |
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| GTF2IRD1-ALK-20-GORE | 20 (40 μL) | 200 μL |
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| GTF2IRD1-ALK-20-GOOR | 20 (40 μL) | 200 μL |
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| GTF2IRD1-ALK-20-GOGO | 20 (40 μL) | 200 μL |
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| GTF2IRD1-ALK-20-GOGR | 20 (40 μL) | 200 μL |
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| GTF2IRD1-ALK-20-GOAQ | 20 (40 μL) | 200 μL |
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| GTF2IRD1-ALK-20-GRRE | 20 (40 μL) | 200 μL |
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| GTF2IRD1-ALK-20-GROR | 20 (40 μL) | 200 μL |
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| GTF2IRD1-ALK-20-GRGO | 20 (40 μL) | 200 μL |
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| GTF2IRD1-ALK-20-GRGR | 20 (40 μL) | 200 μL |
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| GTF2IRD1-ALK-20-GRAQ | 20 (40 μL) | 200 μL |
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| GTF2IRD1-ALK-20-AQRE | 20 (40 μL) | 200 μL |
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| GTF2IRD1-ALK-20-AQOR | 20 (40 μL) | 200 μL |
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| GTF2IRD1-ALK-20-AQGO | 20 (40 μL) | 200 μL |
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| GTF2IRD1-ALK-20-AQGR | 20 (40 μL) | 200 μL |
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| GTF2IRD1-ALK-20-AQAQ | 20 (40 μL) | 200 μL |
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ALK Gene Summary
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
Gene Name: ALK Receptor Tyrosine Kinase
Chromosome: CHR2: 29415639 -30144477
Locus: 2p23.2-p23.1
GTF2IRD1 Gene Summary
The protein encoded by this gene contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. This gene plays a role in craniofacial and cognitive development and mutations have been associated with Williams-Beuren syndrome, a multisystem developmental disorder caused by deletion of multiple genes at 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Gene Name: GTF2I Repeat Domain Containing 1
Chromosome: CHR7: 73868119 -74016920
Locus: 7q11.23
Gene Diseases
The GTF2IRD1 ALK Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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