GTF2H3-PGC Fusion FISH Probe
The GTF2H3-PGC Fusion FISH Probe is used to confirm a fusion of the GTF2H3 and PGC genes. The fusion of the GTF2H3 and PGC genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GTF2H3-PGC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GTF2H3-PGC-20-RERE | 20 (40 μL) | 200 μL |
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| GTF2H3-PGC-20-REOR | 20 (40 μL) | 200 μL |
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| GTF2H3-PGC-20-REGO | 20 (40 μL) | 200 μL |
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| GTF2H3-PGC-20-REGR | 20 (40 μL) | 200 μL |
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| GTF2H3-PGC-20-REAQ | 20 (40 μL) | 200 μL |
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| GTF2H3-PGC-20-ORRE | 20 (40 μL) | 200 μL |
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| GTF2H3-PGC-20-OROR | 20 (40 μL) | 200 μL |
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| GTF2H3-PGC-20-ORGO | 20 (40 μL) | 200 μL |
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| GTF2H3-PGC-20-ORAQ | 20 (40 μL) | 200 μL |
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| GTF2H3-PGC-20-GORE | 20 (40 μL) | 200 μL |
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| GTF2H3-PGC-20-GOOR | 20 (40 μL) | 200 μL |
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| GTF2H3-PGC-20-GOGO | 20 (40 μL) | 200 μL |
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| GTF2H3-PGC-20-GOGR | 20 (40 μL) | 200 μL |
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| GTF2H3-PGC-20-GOAQ | 20 (40 μL) | 200 μL |
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| GTF2H3-PGC-20-GRRE | 20 (40 μL) | 200 μL |
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| GTF2H3-PGC-20-GROR | 20 (40 μL) | 200 μL |
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| GTF2H3-PGC-20-GRGO | 20 (40 μL) | 200 μL |
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| GTF2H3-PGC-20-GRGR | 20 (40 μL) | 200 μL |
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| GTF2H3-PGC-20-GRAQ | 20 (40 μL) | 200 μL |
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| GTF2H3-PGC-20-AQRE | 20 (40 μL) | 200 μL |
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| GTF2H3-PGC-20-AQOR | 20 (40 μL) | 200 μL |
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| GTF2H3-PGC-20-AQGO | 20 (40 μL) | 200 μL |
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| GTF2H3-PGC-20-AQGR | 20 (40 μL) | 200 μL |
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| GTF2H3-PGC-20-AQAQ | 20 (40 μL) | 200 μL |
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GTF2H3 Gene Summary
This gene encodes a member of the TFB4 family. The encoded protein is a subunit of the core-TFIIH basal transcription factor and localizes to the nucleus. The encoded protein is involved in RNA transcription by RNA polymerase II and nucleotide excision repair and associates with the Cdk-activating kinase complex. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 14. [provided by RefSeq, Dec 2012]
Gene Name: General Transcription Factor IIH Subunit 3
Chromosome: CHR12: 124118380 -124145334
Locus: 12q24.31
PGC Gene Summary
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]
Gene Name: Progastricsin
Chromosome: CHR6: 41704448 -41715139
Locus: 6p21.1
Gene Diseases
The GTF2H3 PGC Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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