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GTF2H3-NCOR2 Fusion FISH Probe

The GTF2H3-NCOR2 Fusion FISH Probe is used to confirm a fusion of the GTF2H3 and NCOR2 genes. The fusion of the GTF2H3 and NCOR2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
GTF2H3-NCOR2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
GTF2H3-NCOR2-20-RERE 20 (40 μL) 200 μL
GTF2H3-NCOR2-20-REOR 20 (40 μL) 200 μL
GTF2H3-NCOR2-20-REGO 20 (40 μL) 200 μL
GTF2H3-NCOR2-20-REGR 20 (40 μL) 200 μL
GTF2H3-NCOR2-20-REAQ 20 (40 μL) 200 μL
GTF2H3-NCOR2-20-ORRE 20 (40 μL) 200 μL
GTF2H3-NCOR2-20-OROR 20 (40 μL) 200 μL
GTF2H3-NCOR2-20-ORGO 20 (40 μL) 200 μL
GTF2H3-NCOR2-20-ORAQ 20 (40 μL) 200 μL
GTF2H3-NCOR2-20-GORE 20 (40 μL) 200 μL
GTF2H3-NCOR2-20-GOOR 20 (40 μL) 200 μL
GTF2H3-NCOR2-20-GOGO 20 (40 μL) 200 μL
GTF2H3-NCOR2-20-GOGR 20 (40 μL) 200 μL
GTF2H3-NCOR2-20-GOAQ 20 (40 μL) 200 μL
GTF2H3-NCOR2-20-GRRE 20 (40 μL) 200 μL
GTF2H3-NCOR2-20-GROR 20 (40 μL) 200 μL
GTF2H3-NCOR2-20-GRGO 20 (40 μL) 200 μL
GTF2H3-NCOR2-20-GRGR 20 (40 μL) 200 μL
GTF2H3-NCOR2-20-GRAQ 20 (40 μL) 200 μL
GTF2H3-NCOR2-20-AQRE 20 (40 μL) 200 μL
GTF2H3-NCOR2-20-AQOR 20 (40 μL) 200 μL
GTF2H3-NCOR2-20-AQGO 20 (40 μL) 200 μL
GTF2H3-NCOR2-20-AQGR 20 (40 μL) 200 μL
GTF2H3-NCOR2-20-AQAQ 20 (40 μL) 200 μL

GTF2H3 Gene Summary

This gene encodes a member of the TFB4 family. The encoded protein is a subunit of the core-TFIIH basal transcription factor and localizes to the nucleus. The encoded protein is involved in RNA transcription by RNA polymerase II and nucleotide excision repair and associates with the Cdk-activating kinase complex. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 14. [provided by RefSeq, Dec 2012]

Gene Name: General Transcription Factor IIH Subunit 3

Chromosome: CHR12: 124118380 -124145334

Locus: 12q24.31

NCOR2 Gene Summary

This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]

Gene Name: Nuclear Receptor Corepressor 2

Chromosome: CHR12: 124808956 -125052010

Locus: 12q24.31

Gene Diseases

The GTF2H3 NCOR2 Fusion has been associated with the following diseases:

Disease Name
Skin Cutaneous Melanoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.