GTF2H3-NCOR2 Fusion FISH Probe
The GTF2H3-NCOR2 Fusion FISH Probe is used to confirm a fusion of the GTF2H3 and NCOR2 genes. The fusion of the GTF2H3 and NCOR2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GTF2H3-NCOR2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GTF2H3-NCOR2-20-RERE | 20 (40 μL) | 200 μL |
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| GTF2H3-NCOR2-20-REOR | 20 (40 μL) | 200 μL |
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| GTF2H3-NCOR2-20-REGO | 20 (40 μL) | 200 μL |
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| GTF2H3-NCOR2-20-REGR | 20 (40 μL) | 200 μL |
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| GTF2H3-NCOR2-20-REAQ | 20 (40 μL) | 200 μL |
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| GTF2H3-NCOR2-20-ORRE | 20 (40 μL) | 200 μL |
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| GTF2H3-NCOR2-20-OROR | 20 (40 μL) | 200 μL |
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| GTF2H3-NCOR2-20-ORGO | 20 (40 μL) | 200 μL |
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| GTF2H3-NCOR2-20-ORAQ | 20 (40 μL) | 200 μL |
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| GTF2H3-NCOR2-20-GORE | 20 (40 μL) | 200 μL |
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| GTF2H3-NCOR2-20-GOOR | 20 (40 μL) | 200 μL |
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| GTF2H3-NCOR2-20-GOGO | 20 (40 μL) | 200 μL |
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| GTF2H3-NCOR2-20-GOGR | 20 (40 μL) | 200 μL |
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| GTF2H3-NCOR2-20-GOAQ | 20 (40 μL) | 200 μL |
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| GTF2H3-NCOR2-20-GRRE | 20 (40 μL) | 200 μL |
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| GTF2H3-NCOR2-20-GROR | 20 (40 μL) | 200 μL |
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| GTF2H3-NCOR2-20-GRGO | 20 (40 μL) | 200 μL |
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| GTF2H3-NCOR2-20-GRGR | 20 (40 μL) | 200 μL |
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| GTF2H3-NCOR2-20-GRAQ | 20 (40 μL) | 200 μL |
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| GTF2H3-NCOR2-20-AQRE | 20 (40 μL) | 200 μL |
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| GTF2H3-NCOR2-20-AQOR | 20 (40 μL) | 200 μL |
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| GTF2H3-NCOR2-20-AQGO | 20 (40 μL) | 200 μL |
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| GTF2H3-NCOR2-20-AQGR | 20 (40 μL) | 200 μL |
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| GTF2H3-NCOR2-20-AQAQ | 20 (40 μL) | 200 μL |
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GTF2H3 Gene Summary
This gene encodes a member of the TFB4 family. The encoded protein is a subunit of the core-TFIIH basal transcription factor and localizes to the nucleus. The encoded protein is involved in RNA transcription by RNA polymerase II and nucleotide excision repair and associates with the Cdk-activating kinase complex. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 14. [provided by RefSeq, Dec 2012]
Gene Name: General Transcription Factor IIH Subunit 3
Chromosome: CHR12: 124118380 -124145334
Locus: 12q24.31
NCOR2 Gene Summary
This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]
Gene Name: Nuclear Receptor Corepressor 2
Chromosome: CHR12: 124808956 -125052010
Locus: 12q24.31
Gene Diseases
The GTF2H3 NCOR2 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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