GSTP1-SF3B2 Fusion FISH Probe
The GSTP1-SF3B2 Fusion FISH Probe is used to confirm a fusion of the GSTP1 and SF3B2 genes. The fusion of the GSTP1 and SF3B2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GSTP1-SF3B2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GSTP1-SF3B2-20-RERE | 20 (40 μL) | 200 μL |
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| GSTP1-SF3B2-20-REOR | 20 (40 μL) | 200 μL |
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| GSTP1-SF3B2-20-REGO | 20 (40 μL) | 200 μL |
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| GSTP1-SF3B2-20-REGR | 20 (40 μL) | 200 μL |
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| GSTP1-SF3B2-20-REAQ | 20 (40 μL) | 200 μL |
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| GSTP1-SF3B2-20-ORRE | 20 (40 μL) | 200 μL |
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| GSTP1-SF3B2-20-OROR | 20 (40 μL) | 200 μL |
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| GSTP1-SF3B2-20-ORGO | 20 (40 μL) | 200 μL |
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| GSTP1-SF3B2-20-ORAQ | 20 (40 μL) | 200 μL |
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| GSTP1-SF3B2-20-GORE | 20 (40 μL) | 200 μL |
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| GSTP1-SF3B2-20-GOOR | 20 (40 μL) | 200 μL |
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| GSTP1-SF3B2-20-GOGO | 20 (40 μL) | 200 μL |
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| GSTP1-SF3B2-20-GOGR | 20 (40 μL) | 200 μL |
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| GSTP1-SF3B2-20-GOAQ | 20 (40 μL) | 200 μL |
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| GSTP1-SF3B2-20-GRRE | 20 (40 μL) | 200 μL |
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| GSTP1-SF3B2-20-GROR | 20 (40 μL) | 200 μL |
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| GSTP1-SF3B2-20-GRGO | 20 (40 μL) | 200 μL |
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| GSTP1-SF3B2-20-GRGR | 20 (40 μL) | 200 μL |
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| GSTP1-SF3B2-20-GRAQ | 20 (40 μL) | 200 μL |
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| GSTP1-SF3B2-20-AQRE | 20 (40 μL) | 200 μL |
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| GSTP1-SF3B2-20-AQOR | 20 (40 μL) | 200 μL |
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| GSTP1-SF3B2-20-AQGO | 20 (40 μL) | 200 μL |
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| GSTP1-SF3B2-20-AQGR | 20 (40 μL) | 200 μL |
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| GSTP1-SF3B2-20-AQAQ | 20 (40 μL) | 200 μL |
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GSTP1 Gene Summary
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]
Gene Name: Glutathione S-transferase Pi 1
Chromosome: CHR11: 67351065 -67354124
Locus: 11q13.2
SF3B2 Gene Summary
This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. [provided by RefSeq, Jul 2008]
Gene Name: Splicing Factor 3b Subunit 2
Chromosome: CHR11: 65819815 -65836382
Locus: 11q13.1
Gene Diseases
The GSTP1 SF3B2 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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