GSN-HLA-DPB1 Fusion FISH Probe
The GSN-HLA-DPB1 Fusion FISH Probe is used to confirm a fusion of the GSN and HLA-DPB1 genes. The fusion of the GSN and HLA-DPB1 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GSN-HLA-DPB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GSN-HLA-DPB1-20-RERE | 20 (40 μL) | 200 μL |
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| GSN-HLA-DPB1-20-REOR | 20 (40 μL) | 200 μL |
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| GSN-HLA-DPB1-20-REGO | 20 (40 μL) | 200 μL |
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| GSN-HLA-DPB1-20-REGR | 20 (40 μL) | 200 μL |
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| GSN-HLA-DPB1-20-REAQ | 20 (40 μL) | 200 μL |
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| GSN-HLA-DPB1-20-ORRE | 20 (40 μL) | 200 μL |
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| GSN-HLA-DPB1-20-OROR | 20 (40 μL) | 200 μL |
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| GSN-HLA-DPB1-20-ORGO | 20 (40 μL) | 200 μL |
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| GSN-HLA-DPB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| GSN-HLA-DPB1-20-GORE | 20 (40 μL) | 200 μL |
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| GSN-HLA-DPB1-20-GOOR | 20 (40 μL) | 200 μL |
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| GSN-HLA-DPB1-20-GOGO | 20 (40 μL) | 200 μL |
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| GSN-HLA-DPB1-20-GOGR | 20 (40 μL) | 200 μL |
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| GSN-HLA-DPB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| GSN-HLA-DPB1-20-GRRE | 20 (40 μL) | 200 μL |
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| GSN-HLA-DPB1-20-GROR | 20 (40 μL) | 200 μL |
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| GSN-HLA-DPB1-20-GRGO | 20 (40 μL) | 200 μL |
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| GSN-HLA-DPB1-20-GRGR | 20 (40 μL) | 200 μL |
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| GSN-HLA-DPB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| GSN-HLA-DPB1-20-AQRE | 20 (40 μL) | 200 μL |
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| GSN-HLA-DPB1-20-AQOR | 20 (40 μL) | 200 μL |
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| GSN-HLA-DPB1-20-AQGO | 20 (40 μL) | 200 μL |
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| GSN-HLA-DPB1-20-AQGR | 20 (40 μL) | 200 μL |
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| GSN-HLA-DPB1-20-AQAQ | 20 (40 μL) | 200 μL |
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GSN Gene Summary
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Gelsolin
Chromosome: CHR9: 124030379 -124095120
Locus: 9q33.2
HLA-DPB1 Gene Summary
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]
Gene Name: Major Histocompatibility Complex, Class II, DP Beta 1
Chromosome: CHR6_mann_hap4: 4501242 -4515019
Locus: 6p21.32
Gene Diseases
The GSN HLA-DPB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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