GSN-AKAP13 Fusion FISH Probe
The GSN-AKAP13 Fusion FISH Probe is used to confirm a fusion of the GSN and AKAP13 genes. The fusion of the GSN and AKAP13 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GSN-AKAP13-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GSN-AKAP13-20-RERE | 20 (40 μL) | 200 μL |
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| GSN-AKAP13-20-REOR | 20 (40 μL) | 200 μL |
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| GSN-AKAP13-20-REGO | 20 (40 μL) | 200 μL |
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| GSN-AKAP13-20-REGR | 20 (40 μL) | 200 μL |
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| GSN-AKAP13-20-REAQ | 20 (40 μL) | 200 μL |
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| GSN-AKAP13-20-ORRE | 20 (40 μL) | 200 μL |
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| GSN-AKAP13-20-OROR | 20 (40 μL) | 200 μL |
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| GSN-AKAP13-20-ORGO | 20 (40 μL) | 200 μL |
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| GSN-AKAP13-20-ORAQ | 20 (40 μL) | 200 μL |
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| GSN-AKAP13-20-GORE | 20 (40 μL) | 200 μL |
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| GSN-AKAP13-20-GOOR | 20 (40 μL) | 200 μL |
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| GSN-AKAP13-20-GOGO | 20 (40 μL) | 200 μL |
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| GSN-AKAP13-20-GOGR | 20 (40 μL) | 200 μL |
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| GSN-AKAP13-20-GOAQ | 20 (40 μL) | 200 μL |
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| GSN-AKAP13-20-GRRE | 20 (40 μL) | 200 μL |
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| GSN-AKAP13-20-GROR | 20 (40 μL) | 200 μL |
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| GSN-AKAP13-20-GRGO | 20 (40 μL) | 200 μL |
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| GSN-AKAP13-20-GRGR | 20 (40 μL) | 200 μL |
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| GSN-AKAP13-20-GRAQ | 20 (40 μL) | 200 μL |
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| GSN-AKAP13-20-AQRE | 20 (40 μL) | 200 μL |
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| GSN-AKAP13-20-AQOR | 20 (40 μL) | 200 μL |
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| GSN-AKAP13-20-AQGO | 20 (40 μL) | 200 μL |
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| GSN-AKAP13-20-AQGR | 20 (40 μL) | 200 μL |
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| GSN-AKAP13-20-AQAQ | 20 (40 μL) | 200 μL |
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GSN Gene Summary
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Gelsolin
Chromosome: CHR9: 124030379 -124095120
Locus: 9q33.2
AKAP13 Gene Summary
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]
Gene Name: A-kinase Anchoring Protein 13
Chromosome: CHR15: 85923870 -86292586
Locus: 15q25.3
Gene Diseases
The GSN AKAP13 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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