GSK3B-SEMA5B Fusion FISH Probe
The GSK3B-SEMA5B Fusion FISH Probe is used to confirm a fusion of the GSK3B and SEMA5B genes. The fusion of the GSK3B and SEMA5B genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GSK3B-SEMA5B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GSK3B-SEMA5B-20-RERE | 20 (40 μL) | 200 μL |
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| GSK3B-SEMA5B-20-REOR | 20 (40 μL) | 200 μL |
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| GSK3B-SEMA5B-20-REGO | 20 (40 μL) | 200 μL |
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| GSK3B-SEMA5B-20-REGR | 20 (40 μL) | 200 μL |
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| GSK3B-SEMA5B-20-REAQ | 20 (40 μL) | 200 μL |
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| GSK3B-SEMA5B-20-ORRE | 20 (40 μL) | 200 μL |
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| GSK3B-SEMA5B-20-OROR | 20 (40 μL) | 200 μL |
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| GSK3B-SEMA5B-20-ORGO | 20 (40 μL) | 200 μL |
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| GSK3B-SEMA5B-20-ORAQ | 20 (40 μL) | 200 μL |
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| GSK3B-SEMA5B-20-GORE | 20 (40 μL) | 200 μL |
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| GSK3B-SEMA5B-20-GOOR | 20 (40 μL) | 200 μL |
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| GSK3B-SEMA5B-20-GOGO | 20 (40 μL) | 200 μL |
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| GSK3B-SEMA5B-20-GOGR | 20 (40 μL) | 200 μL |
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| GSK3B-SEMA5B-20-GOAQ | 20 (40 μL) | 200 μL |
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| GSK3B-SEMA5B-20-GRRE | 20 (40 μL) | 200 μL |
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| GSK3B-SEMA5B-20-GROR | 20 (40 μL) | 200 μL |
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| GSK3B-SEMA5B-20-GRGO | 20 (40 μL) | 200 μL |
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| GSK3B-SEMA5B-20-GRGR | 20 (40 μL) | 200 μL |
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| GSK3B-SEMA5B-20-GRAQ | 20 (40 μL) | 200 μL |
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| GSK3B-SEMA5B-20-AQRE | 20 (40 μL) | 200 μL |
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| GSK3B-SEMA5B-20-AQOR | 20 (40 μL) | 200 μL |
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| GSK3B-SEMA5B-20-AQGO | 20 (40 μL) | 200 μL |
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| GSK3B-SEMA5B-20-AQGR | 20 (40 μL) | 200 μL |
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| GSK3B-SEMA5B-20-AQAQ | 20 (40 μL) | 200 μL |
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GSK3B Gene Summary
The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]
Gene Name: Glycogen Synthase Kinase 3 Beta
Chromosome: CHR3: 119540801 -119813264
Locus: 3q13.33
SEMA5B Gene Summary
This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Name: Semaphorin 5B
Chromosome: CHR3: 122628042 -122746576
Locus: 3q21.1
Gene Diseases
The GSK3B SEMA5B Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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