GSK3B-BEST3 Fusion FISH Probe
The GSK3B-BEST3 Fusion FISH Probe is used to confirm a fusion of the GSK3B and BEST3 genes. The fusion of the GSK3B and BEST3 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GSK3B-BEST3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GSK3B-BEST3-20-RERE | 20 (40 μL) | 200 μL |
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| GSK3B-BEST3-20-REOR | 20 (40 μL) | 200 μL |
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| GSK3B-BEST3-20-REGO | 20 (40 μL) | 200 μL |
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| GSK3B-BEST3-20-REGR | 20 (40 μL) | 200 μL |
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| GSK3B-BEST3-20-REAQ | 20 (40 μL) | 200 μL |
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| GSK3B-BEST3-20-ORRE | 20 (40 μL) | 200 μL |
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| GSK3B-BEST3-20-OROR | 20 (40 μL) | 200 μL |
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| GSK3B-BEST3-20-ORGO | 20 (40 μL) | 200 μL |
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| GSK3B-BEST3-20-ORAQ | 20 (40 μL) | 200 μL |
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| GSK3B-BEST3-20-GORE | 20 (40 μL) | 200 μL |
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| GSK3B-BEST3-20-GOOR | 20 (40 μL) | 200 μL |
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| GSK3B-BEST3-20-GOGO | 20 (40 μL) | 200 μL |
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| GSK3B-BEST3-20-GOGR | 20 (40 μL) | 200 μL |
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| GSK3B-BEST3-20-GOAQ | 20 (40 μL) | 200 μL |
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| GSK3B-BEST3-20-GRRE | 20 (40 μL) | 200 μL |
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| GSK3B-BEST3-20-GROR | 20 (40 μL) | 200 μL |
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| GSK3B-BEST3-20-GRGO | 20 (40 μL) | 200 μL |
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| GSK3B-BEST3-20-GRGR | 20 (40 μL) | 200 μL |
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| GSK3B-BEST3-20-GRAQ | 20 (40 μL) | 200 μL |
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| GSK3B-BEST3-20-AQRE | 20 (40 μL) | 200 μL |
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| GSK3B-BEST3-20-AQOR | 20 (40 μL) | 200 μL |
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| GSK3B-BEST3-20-AQGO | 20 (40 μL) | 200 μL |
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| GSK3B-BEST3-20-AQGR | 20 (40 μL) | 200 μL |
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| GSK3B-BEST3-20-AQAQ | 20 (40 μL) | 200 μL |
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GSK3B Gene Summary
The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]
Gene Name: Glycogen Synthase Kinase 3 Beta
Chromosome: CHR3: 119540801 -119813264
Locus: 3q13.33
BEST3 Gene Summary
BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).[supplied by OMIM, Mar 2008]
Gene Name: Bestrophin 3
Chromosome: CHR12: 70047388 -70093196
Locus: 12q15
Gene Diseases
The GSK3B BEST3 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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