GRN-PLAT Fusion FISH Probe
The GRN-PLAT Fusion FISH Probe is used to confirm a fusion of the GRN and PLAT genes. The fusion of the GRN and PLAT genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GRN-PLAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GRN-PLAT-20-RERE | 20 (40 μL) | 200 μL |
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| GRN-PLAT-20-REOR | 20 (40 μL) | 200 μL |
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| GRN-PLAT-20-REGO | 20 (40 μL) | 200 μL |
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| GRN-PLAT-20-REGR | 20 (40 μL) | 200 μL |
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| GRN-PLAT-20-REAQ | 20 (40 μL) | 200 μL |
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| GRN-PLAT-20-ORRE | 20 (40 μL) | 200 μL |
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| GRN-PLAT-20-OROR | 20 (40 μL) | 200 μL |
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| GRN-PLAT-20-ORGO | 20 (40 μL) | 200 μL |
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| GRN-PLAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| GRN-PLAT-20-GORE | 20 (40 μL) | 200 μL |
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| GRN-PLAT-20-GOOR | 20 (40 μL) | 200 μL |
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| GRN-PLAT-20-GOGO | 20 (40 μL) | 200 μL |
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| GRN-PLAT-20-GOGR | 20 (40 μL) | 200 μL |
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| GRN-PLAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| GRN-PLAT-20-GRRE | 20 (40 μL) | 200 μL |
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| GRN-PLAT-20-GROR | 20 (40 μL) | 200 μL |
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| GRN-PLAT-20-GRGO | 20 (40 μL) | 200 μL |
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| GRN-PLAT-20-GRGR | 20 (40 μL) | 200 μL |
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| GRN-PLAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| GRN-PLAT-20-AQRE | 20 (40 μL) | 200 μL |
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| GRN-PLAT-20-AQOR | 20 (40 μL) | 200 μL |
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| GRN-PLAT-20-AQGO | 20 (40 μL) | 200 μL |
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| GRN-PLAT-20-AQGR | 20 (40 μL) | 200 μL |
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| GRN-PLAT-20-AQAQ | 20 (40 μL) | 200 μL |
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GRN Gene Summary
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
Gene Name: Granulin Precursor
Chromosome: CHR17: 42422490 -42430470
Locus: 17q21.31
PLAT Gene Summary
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Plasminogen Activator, Tissue Type
Chromosome: CHR8: 42032235 -42065194
Locus: 8p11.21
Gene Diseases
The GRN PLAT Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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