GRN-NCALD Fusion FISH Probe
The GRN-NCALD Fusion FISH Probe is used to confirm a fusion of the GRN and NCALD genes. The fusion of the GRN and NCALD genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GRN-NCALD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GRN-NCALD-20-RERE | 20 (40 μL) | 200 μL |
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| GRN-NCALD-20-REOR | 20 (40 μL) | 200 μL |
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| GRN-NCALD-20-REGO | 20 (40 μL) | 200 μL |
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| GRN-NCALD-20-REGR | 20 (40 μL) | 200 μL |
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| GRN-NCALD-20-REAQ | 20 (40 μL) | 200 μL |
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| GRN-NCALD-20-ORRE | 20 (40 μL) | 200 μL |
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| GRN-NCALD-20-OROR | 20 (40 μL) | 200 μL |
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| GRN-NCALD-20-ORGO | 20 (40 μL) | 200 μL |
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| GRN-NCALD-20-ORAQ | 20 (40 μL) | 200 μL |
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| GRN-NCALD-20-GORE | 20 (40 μL) | 200 μL |
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| GRN-NCALD-20-GOOR | 20 (40 μL) | 200 μL |
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| GRN-NCALD-20-GOGO | 20 (40 μL) | 200 μL |
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| GRN-NCALD-20-GOGR | 20 (40 μL) | 200 μL |
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| GRN-NCALD-20-GOAQ | 20 (40 μL) | 200 μL |
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| GRN-NCALD-20-GRRE | 20 (40 μL) | 200 μL |
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| GRN-NCALD-20-GROR | 20 (40 μL) | 200 μL |
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| GRN-NCALD-20-GRGO | 20 (40 μL) | 200 μL |
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| GRN-NCALD-20-GRGR | 20 (40 μL) | 200 μL |
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| GRN-NCALD-20-GRAQ | 20 (40 μL) | 200 μL |
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| GRN-NCALD-20-AQRE | 20 (40 μL) | 200 μL |
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| GRN-NCALD-20-AQOR | 20 (40 μL) | 200 μL |
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| GRN-NCALD-20-AQGO | 20 (40 μL) | 200 μL |
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| GRN-NCALD-20-AQGR | 20 (40 μL) | 200 μL |
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| GRN-NCALD-20-AQAQ | 20 (40 μL) | 200 μL |
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GRN Gene Summary
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
Gene Name: Granulin Precursor
Chromosome: CHR17: 42422490 -42430470
Locus: 17q21.31
NCALD Gene Summary
This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Neurocalcin Delta
Chromosome: CHR8: 102698769 -103137135
Locus: 8q22.3
Gene Diseases
The GRN NCALD Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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