GRN-ERBB3 Fusion FISH Probe
The GRN-ERBB3 Fusion FISH Probe is used to confirm a fusion of the GRN and ERBB3 genes. The fusion of the GRN and ERBB3 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GRN-ERBB3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| GRN-ERBB3-20-RERE | 20 (40 μL) | 200 μL |
|
|
| GRN-ERBB3-20-REOR | 20 (40 μL) | 200 μL |
|
|
| GRN-ERBB3-20-REGO | 20 (40 μL) | 200 μL |
|
|
| GRN-ERBB3-20-REGR | 20 (40 μL) | 200 μL |
|
|
| GRN-ERBB3-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| GRN-ERBB3-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| GRN-ERBB3-20-OROR | 20 (40 μL) | 200 μL |
|
|
| GRN-ERBB3-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| GRN-ERBB3-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| GRN-ERBB3-20-GORE | 20 (40 μL) | 200 μL |
|
|
| GRN-ERBB3-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| GRN-ERBB3-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| GRN-ERBB3-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| GRN-ERBB3-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| GRN-ERBB3-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| GRN-ERBB3-20-GROR | 20 (40 μL) | 200 μL |
|
|
| GRN-ERBB3-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| GRN-ERBB3-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| GRN-ERBB3-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| GRN-ERBB3-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| GRN-ERBB3-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| GRN-ERBB3-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| GRN-ERBB3-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| GRN-ERBB3-20-AQAQ | 20 (40 μL) | 200 μL |
|
ERBB3 Gene Summary
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Name: Erb-b2 Receptor Tyrosine Kinase 3
Chromosome: CHR12: 56473808 -56497291
Locus: 12q13.2
GRN Gene Summary
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
Gene Name: Granulin Precursor
Chromosome: CHR17: 42422490 -42430470
Locus: 17q21.31
Gene Diseases
The GRN ERBB3 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|