GRN-COL11A1 Fusion FISH Probe
The GRN-COL11A1 Fusion FISH Probe is used to confirm a fusion of the GRN and COL11A1 genes. The fusion of the GRN and COL11A1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GRN-COL11A1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GRN-COL11A1-20-RERE | 20 (40 μL) | 200 μL |
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| GRN-COL11A1-20-REOR | 20 (40 μL) | 200 μL |
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| GRN-COL11A1-20-REGO | 20 (40 μL) | 200 μL |
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| GRN-COL11A1-20-REGR | 20 (40 μL) | 200 μL |
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| GRN-COL11A1-20-REAQ | 20 (40 μL) | 200 μL |
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| GRN-COL11A1-20-ORRE | 20 (40 μL) | 200 μL |
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| GRN-COL11A1-20-OROR | 20 (40 μL) | 200 μL |
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| GRN-COL11A1-20-ORGO | 20 (40 μL) | 200 μL |
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| GRN-COL11A1-20-ORAQ | 20 (40 μL) | 200 μL |
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| GRN-COL11A1-20-GORE | 20 (40 μL) | 200 μL |
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| GRN-COL11A1-20-GOOR | 20 (40 μL) | 200 μL |
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| GRN-COL11A1-20-GOGO | 20 (40 μL) | 200 μL |
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| GRN-COL11A1-20-GOGR | 20 (40 μL) | 200 μL |
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| GRN-COL11A1-20-GOAQ | 20 (40 μL) | 200 μL |
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| GRN-COL11A1-20-GRRE | 20 (40 μL) | 200 μL |
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| GRN-COL11A1-20-GROR | 20 (40 μL) | 200 μL |
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| GRN-COL11A1-20-GRGO | 20 (40 μL) | 200 μL |
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| GRN-COL11A1-20-GRGR | 20 (40 μL) | 200 μL |
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| GRN-COL11A1-20-GRAQ | 20 (40 μL) | 200 μL |
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| GRN-COL11A1-20-AQRE | 20 (40 μL) | 200 μL |
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| GRN-COL11A1-20-AQOR | 20 (40 μL) | 200 μL |
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| GRN-COL11A1-20-AQGO | 20 (40 μL) | 200 μL |
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| GRN-COL11A1-20-AQGR | 20 (40 μL) | 200 μL |
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| GRN-COL11A1-20-AQAQ | 20 (40 μL) | 200 μL |
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COL11A1 Gene Summary
This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Mutations in this gene are associated with type II Stickler syndrome and with Marshall syndrome. A single-nucleotide polymorphism in this gene is also associated with susceptibility to lumbar disc herniation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009]
Gene Name: Collagen Type XI Alpha 1 Chain
Chromosome: CHR1: 103342022 -103574052
Locus: 1p21.1
GRN Gene Summary
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
Gene Name: Granulin Precursor
Chromosome: CHR17: 42422490 -42430470
Locus: 17q21.31
Gene Diseases
The GRN COL11A1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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