GRN-CLCN3 Fusion FISH Probe
The GRN-CLCN3 Fusion FISH Probe is used to confirm a fusion of the GRN and CLCN3 genes. The fusion of the GRN and CLCN3 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GRN-CLCN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GRN-CLCN3-20-RERE | 20 (40 μL) | 200 μL |
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| GRN-CLCN3-20-REOR | 20 (40 μL) | 200 μL |
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| GRN-CLCN3-20-REGO | 20 (40 μL) | 200 μL |
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| GRN-CLCN3-20-REGR | 20 (40 μL) | 200 μL |
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| GRN-CLCN3-20-REAQ | 20 (40 μL) | 200 μL |
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| GRN-CLCN3-20-ORRE | 20 (40 μL) | 200 μL |
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| GRN-CLCN3-20-OROR | 20 (40 μL) | 200 μL |
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| GRN-CLCN3-20-ORGO | 20 (40 μL) | 200 μL |
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| GRN-CLCN3-20-ORAQ | 20 (40 μL) | 200 μL |
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| GRN-CLCN3-20-GORE | 20 (40 μL) | 200 μL |
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| GRN-CLCN3-20-GOOR | 20 (40 μL) | 200 μL |
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| GRN-CLCN3-20-GOGO | 20 (40 μL) | 200 μL |
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| GRN-CLCN3-20-GOGR | 20 (40 μL) | 200 μL |
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| GRN-CLCN3-20-GOAQ | 20 (40 μL) | 200 μL |
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| GRN-CLCN3-20-GRRE | 20 (40 μL) | 200 μL |
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| GRN-CLCN3-20-GROR | 20 (40 μL) | 200 μL |
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| GRN-CLCN3-20-GRGO | 20 (40 μL) | 200 μL |
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| GRN-CLCN3-20-GRGR | 20 (40 μL) | 200 μL |
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| GRN-CLCN3-20-GRAQ | 20 (40 μL) | 200 μL |
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| GRN-CLCN3-20-AQRE | 20 (40 μL) | 200 μL |
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| GRN-CLCN3-20-AQOR | 20 (40 μL) | 200 μL |
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| GRN-CLCN3-20-AQGO | 20 (40 μL) | 200 μL |
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| GRN-CLCN3-20-AQGR | 20 (40 μL) | 200 μL |
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| GRN-CLCN3-20-AQAQ | 20 (40 μL) | 200 μL |
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CLCN3 Gene Summary
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Chloride Voltage-gated Channel 3
Chromosome: CHR4: 170541671 -170644338
Locus: 4q33
GRN Gene Summary
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
Gene Name: Granulin Precursor
Chromosome: CHR17: 42422490 -42430470
Locus: 17q21.31
Gene Diseases
The GRN CLCN3 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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