GRN-CDKN3 Fusion FISH Probe
The GRN-CDKN3 Fusion FISH Probe is used to confirm a fusion of the GRN and CDKN3 genes. The fusion of the GRN and CDKN3 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GRN-CDKN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GRN-CDKN3-20-RERE | 20 (40 μL) | 200 μL |
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| GRN-CDKN3-20-REOR | 20 (40 μL) | 200 μL |
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| GRN-CDKN3-20-REGO | 20 (40 μL) | 200 μL |
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| GRN-CDKN3-20-REGR | 20 (40 μL) | 200 μL |
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| GRN-CDKN3-20-REAQ | 20 (40 μL) | 200 μL |
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| GRN-CDKN3-20-ORRE | 20 (40 μL) | 200 μL |
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| GRN-CDKN3-20-OROR | 20 (40 μL) | 200 μL |
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| GRN-CDKN3-20-ORGO | 20 (40 μL) | 200 μL |
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| GRN-CDKN3-20-ORAQ | 20 (40 μL) | 200 μL |
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| GRN-CDKN3-20-GORE | 20 (40 μL) | 200 μL |
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| GRN-CDKN3-20-GOOR | 20 (40 μL) | 200 μL |
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| GRN-CDKN3-20-GOGO | 20 (40 μL) | 200 μL |
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| GRN-CDKN3-20-GOGR | 20 (40 μL) | 200 μL |
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| GRN-CDKN3-20-GOAQ | 20 (40 μL) | 200 μL |
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| GRN-CDKN3-20-GRRE | 20 (40 μL) | 200 μL |
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| GRN-CDKN3-20-GROR | 20 (40 μL) | 200 μL |
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| GRN-CDKN3-20-GRGO | 20 (40 μL) | 200 μL |
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| GRN-CDKN3-20-GRGR | 20 (40 μL) | 200 μL |
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| GRN-CDKN3-20-GRAQ | 20 (40 μL) | 200 μL |
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| GRN-CDKN3-20-AQRE | 20 (40 μL) | 200 μL |
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| GRN-CDKN3-20-AQOR | 20 (40 μL) | 200 μL |
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| GRN-CDKN3-20-AQGO | 20 (40 μL) | 200 μL |
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| GRN-CDKN3-20-AQGR | 20 (40 μL) | 200 μL |
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| GRN-CDKN3-20-AQAQ | 20 (40 μL) | 200 μL |
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CDKN3 Gene Summary
The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Name: Cyclin Dependent Kinase Inhibitor 3
Chromosome: CHR14: 54863672 -54886934
Locus: 14q22.2
GRN Gene Summary
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
Gene Name: Granulin Precursor
Chromosome: CHR17: 42422490 -42430470
Locus: 17q21.31
Gene Diseases
The GRN CDKN3 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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