GRM1-CNOT2 Fusion FISH Probe
The GRM1-CNOT2 Fusion FISH Probe is used to confirm a fusion of the GRM1 and CNOT2 genes. The fusion of the GRM1 and CNOT2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GRM1-CNOT2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GRM1-CNOT2-20-RERE | 20 (40 μL) | 200 μL |
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| GRM1-CNOT2-20-REOR | 20 (40 μL) | 200 μL |
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| GRM1-CNOT2-20-REGO | 20 (40 μL) | 200 μL |
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| GRM1-CNOT2-20-REGR | 20 (40 μL) | 200 μL |
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| GRM1-CNOT2-20-REAQ | 20 (40 μL) | 200 μL |
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| GRM1-CNOT2-20-ORRE | 20 (40 μL) | 200 μL |
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| GRM1-CNOT2-20-OROR | 20 (40 μL) | 200 μL |
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| GRM1-CNOT2-20-ORGO | 20 (40 μL) | 200 μL |
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| GRM1-CNOT2-20-ORAQ | 20 (40 μL) | 200 μL |
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| GRM1-CNOT2-20-GORE | 20 (40 μL) | 200 μL |
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| GRM1-CNOT2-20-GOOR | 20 (40 μL) | 200 μL |
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| GRM1-CNOT2-20-GOGO | 20 (40 μL) | 200 μL |
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| GRM1-CNOT2-20-GOGR | 20 (40 μL) | 200 μL |
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| GRM1-CNOT2-20-GOAQ | 20 (40 μL) | 200 μL |
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| GRM1-CNOT2-20-GRRE | 20 (40 μL) | 200 μL |
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| GRM1-CNOT2-20-GROR | 20 (40 μL) | 200 μL |
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| GRM1-CNOT2-20-GRGO | 20 (40 μL) | 200 μL |
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| GRM1-CNOT2-20-GRGR | 20 (40 μL) | 200 μL |
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| GRM1-CNOT2-20-GRAQ | 20 (40 μL) | 200 μL |
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| GRM1-CNOT2-20-AQRE | 20 (40 μL) | 200 μL |
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| GRM1-CNOT2-20-AQOR | 20 (40 μL) | 200 μL |
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| GRM1-CNOT2-20-AQGO | 20 (40 μL) | 200 μL |
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| GRM1-CNOT2-20-AQGR | 20 (40 μL) | 200 μL |
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| GRM1-CNOT2-20-AQAQ | 20 (40 μL) | 200 μL |
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GRM1 Gene Summary
This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Gene Name: Glutamate Metabotropic Receptor 1
Chromosome: CHR6: 146348781 -146758731
Locus: 6q24.3
CNOT2 Gene Summary
This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Name: CCR4-NOT Transcription Complex Subunit 2
Chromosome: CHR12: 70636773 -70748773
Locus: 12q15
Gene Diseases
The GRM1 CNOT2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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