GRIN2A-RASSF8 Fusion FISH Probe
The GRIN2A-RASSF8 Fusion FISH Probe is used to confirm a fusion of the GRIN2A and RASSF8 genes. The fusion of the GRIN2A and RASSF8 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GRIN2A-RASSF8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GRIN2A-RASSF8-20-RERE | 20 (40 μL) | 200 μL |
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| GRIN2A-RASSF8-20-REOR | 20 (40 μL) | 200 μL |
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| GRIN2A-RASSF8-20-REGO | 20 (40 μL) | 200 μL |
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| GRIN2A-RASSF8-20-REGR | 20 (40 μL) | 200 μL |
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| GRIN2A-RASSF8-20-REAQ | 20 (40 μL) | 200 μL |
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| GRIN2A-RASSF8-20-ORRE | 20 (40 μL) | 200 μL |
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| GRIN2A-RASSF8-20-OROR | 20 (40 μL) | 200 μL |
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| GRIN2A-RASSF8-20-ORGO | 20 (40 μL) | 200 μL |
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| GRIN2A-RASSF8-20-ORAQ | 20 (40 μL) | 200 μL |
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| GRIN2A-RASSF8-20-GORE | 20 (40 μL) | 200 μL |
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| GRIN2A-RASSF8-20-GOOR | 20 (40 μL) | 200 μL |
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| GRIN2A-RASSF8-20-GOGO | 20 (40 μL) | 200 μL |
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| GRIN2A-RASSF8-20-GOGR | 20 (40 μL) | 200 μL |
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| GRIN2A-RASSF8-20-GOAQ | 20 (40 μL) | 200 μL |
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| GRIN2A-RASSF8-20-GRRE | 20 (40 μL) | 200 μL |
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| GRIN2A-RASSF8-20-GROR | 20 (40 μL) | 200 μL |
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| GRIN2A-RASSF8-20-GRGO | 20 (40 μL) | 200 μL |
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| GRIN2A-RASSF8-20-GRGR | 20 (40 μL) | 200 μL |
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| GRIN2A-RASSF8-20-GRAQ | 20 (40 μL) | 200 μL |
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| GRIN2A-RASSF8-20-AQRE | 20 (40 μL) | 200 μL |
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| GRIN2A-RASSF8-20-AQOR | 20 (40 μL) | 200 μL |
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| GRIN2A-RASSF8-20-AQGO | 20 (40 μL) | 200 μL |
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| GRIN2A-RASSF8-20-AQGR | 20 (40 μL) | 200 μL |
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| GRIN2A-RASSF8-20-AQAQ | 20 (40 μL) | 200 μL |
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GRIN2A Gene Summary
This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: Glutamate Ionotropic Receptor NMDA Type Subunit 2A
Chromosome: CHR16: 9847264 -10276611
Locus: 16p13.2
RASSF8 Gene Summary
This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration. It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12;22)(p11.2;q13.3) leading to the fusion of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Gene Name: Ras Association Domain Family Member 8
Chromosome: CHR12: 26111963 -26232825
Locus: 12p12.1
Gene Diseases
The GRIN2A RASSF8 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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