GRIK2-MANEA Fusion FISH Probe
The GRIK2-MANEA Fusion FISH Probe is used to confirm a fusion of the GRIK2 and MANEA genes. The fusion of the GRIK2 and MANEA genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GRIK2-MANEA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GRIK2-MANEA-20-RERE | 20 (40 μL) | 200 μL |
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| GRIK2-MANEA-20-REOR | 20 (40 μL) | 200 μL |
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| GRIK2-MANEA-20-REGO | 20 (40 μL) | 200 μL |
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| GRIK2-MANEA-20-REGR | 20 (40 μL) | 200 μL |
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| GRIK2-MANEA-20-REAQ | 20 (40 μL) | 200 μL |
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| GRIK2-MANEA-20-ORRE | 20 (40 μL) | 200 μL |
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| GRIK2-MANEA-20-OROR | 20 (40 μL) | 200 μL |
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| GRIK2-MANEA-20-ORGO | 20 (40 μL) | 200 μL |
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| GRIK2-MANEA-20-ORAQ | 20 (40 μL) | 200 μL |
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| GRIK2-MANEA-20-GORE | 20 (40 μL) | 200 μL |
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| GRIK2-MANEA-20-GOOR | 20 (40 μL) | 200 μL |
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| GRIK2-MANEA-20-GOGO | 20 (40 μL) | 200 μL |
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| GRIK2-MANEA-20-GOGR | 20 (40 μL) | 200 μL |
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| GRIK2-MANEA-20-GOAQ | 20 (40 μL) | 200 μL |
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| GRIK2-MANEA-20-GRRE | 20 (40 μL) | 200 μL |
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| GRIK2-MANEA-20-GROR | 20 (40 μL) | 200 μL |
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| GRIK2-MANEA-20-GRGO | 20 (40 μL) | 200 μL |
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| GRIK2-MANEA-20-GRGR | 20 (40 μL) | 200 μL |
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| GRIK2-MANEA-20-GRAQ | 20 (40 μL) | 200 μL |
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| GRIK2-MANEA-20-AQRE | 20 (40 μL) | 200 μL |
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| GRIK2-MANEA-20-AQOR | 20 (40 μL) | 200 μL |
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| GRIK2-MANEA-20-AQGO | 20 (40 μL) | 200 μL |
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| GRIK2-MANEA-20-AQGR | 20 (40 μL) | 200 μL |
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| GRIK2-MANEA-20-AQAQ | 20 (40 μL) | 200 μL |
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GRIK2 Gene Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive cognitive disability. [provided by RefSeq, Jul 2008]
Gene Name: Glutamate Ionotropic Receptor Kainate Type Subunit 2
Chromosome: CHR6: 101846860 -102517958
Locus: 6q16.3
MANEA Gene Summary
N-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the target protein by an oligosaccharyltransferase complex. This core oligosaccharide is sequentially processed by several ER glycosidases and by an endomannosidase (E.C. 3.2.1.130), such as MANEA, in the Golgi. MANEA catalyzes the release of mono-, di-, and triglucosylmannose oligosaccharides by cleaving the alpha-1,2-mannosidic bond that links them to high-mannose glycans (Hamilton et al., 2005 [PubMed 15677381]).[supplied by OMIM, Sep 2008]
Gene Name: Mannosidase Endo-alpha
Chromosome: CHR6: 96025372 -96057328
Locus: 6q16.1
Gene Diseases
The GRIK2 MANEA Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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