GRID1-GLUD1 Fusion FISH Probe
The GRID1-GLUD1 Fusion FISH Probe is used to confirm a fusion of the GRID1 and GLUD1 genes. The fusion of the GRID1 and GLUD1 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GRID1-GLUD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GRID1-GLUD1-20-RERE | 20 (40 μL) | 200 μL |
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| GRID1-GLUD1-20-REOR | 20 (40 μL) | 200 μL |
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| GRID1-GLUD1-20-REGO | 20 (40 μL) | 200 μL |
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| GRID1-GLUD1-20-REGR | 20 (40 μL) | 200 μL |
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| GRID1-GLUD1-20-REAQ | 20 (40 μL) | 200 μL |
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| GRID1-GLUD1-20-ORRE | 20 (40 μL) | 200 μL |
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| GRID1-GLUD1-20-OROR | 20 (40 μL) | 200 μL |
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| GRID1-GLUD1-20-ORGO | 20 (40 μL) | 200 μL |
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| GRID1-GLUD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| GRID1-GLUD1-20-GORE | 20 (40 μL) | 200 μL |
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| GRID1-GLUD1-20-GOOR | 20 (40 μL) | 200 μL |
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| GRID1-GLUD1-20-GOGO | 20 (40 μL) | 200 μL |
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| GRID1-GLUD1-20-GOGR | 20 (40 μL) | 200 μL |
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| GRID1-GLUD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| GRID1-GLUD1-20-GRRE | 20 (40 μL) | 200 μL |
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| GRID1-GLUD1-20-GROR | 20 (40 μL) | 200 μL |
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| GRID1-GLUD1-20-GRGO | 20 (40 μL) | 200 μL |
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| GRID1-GLUD1-20-GRGR | 20 (40 μL) | 200 μL |
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| GRID1-GLUD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| GRID1-GLUD1-20-AQRE | 20 (40 μL) | 200 μL |
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| GRID1-GLUD1-20-AQOR | 20 (40 μL) | 200 μL |
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| GRID1-GLUD1-20-AQGO | 20 (40 μL) | 200 μL |
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| GRID1-GLUD1-20-AQGR | 20 (40 μL) | 200 μL |
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| GRID1-GLUD1-20-AQAQ | 20 (40 μL) | 200 μL |
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GLUD1 Gene Summary
This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X. [provided by RefSeq, Jan 2016]
Gene Name: Glutamate Dehydrogenase 1
Chromosome: CHR10: 88809958 -88854776
Locus: 10q23.2
GRID1 Gene Summary
This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[provided by RefSeq, Jan 2009]
Gene Name: Glutamate Ionotropic Receptor Delta Type Subunit 1
Chromosome: CHR10: 87359311 -88126250
Locus: 10q23.1-q23.2
Gene Diseases
The GRID1 GLUD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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