GRIA4-NAALAD2 Fusion FISH Probe
The GRIA4-NAALAD2 Fusion FISH Probe is used to confirm a fusion of the GRIA4 and NAALAD2 genes. The fusion of the GRIA4 and NAALAD2 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GRIA4-NAALAD2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GRIA4-NAALAD2-20-RERE | 20 (40 μL) | 200 μL |
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| GRIA4-NAALAD2-20-REOR | 20 (40 μL) | 200 μL |
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| GRIA4-NAALAD2-20-REGO | 20 (40 μL) | 200 μL |
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| GRIA4-NAALAD2-20-REGR | 20 (40 μL) | 200 μL |
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| GRIA4-NAALAD2-20-REAQ | 20 (40 μL) | 200 μL |
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| GRIA4-NAALAD2-20-ORRE | 20 (40 μL) | 200 μL |
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| GRIA4-NAALAD2-20-OROR | 20 (40 μL) | 200 μL |
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| GRIA4-NAALAD2-20-ORGO | 20 (40 μL) | 200 μL |
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| GRIA4-NAALAD2-20-ORAQ | 20 (40 μL) | 200 μL |
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| GRIA4-NAALAD2-20-GORE | 20 (40 μL) | 200 μL |
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| GRIA4-NAALAD2-20-GOOR | 20 (40 μL) | 200 μL |
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| GRIA4-NAALAD2-20-GOGO | 20 (40 μL) | 200 μL |
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| GRIA4-NAALAD2-20-GOGR | 20 (40 μL) | 200 μL |
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| GRIA4-NAALAD2-20-GOAQ | 20 (40 μL) | 200 μL |
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| GRIA4-NAALAD2-20-GRRE | 20 (40 μL) | 200 μL |
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| GRIA4-NAALAD2-20-GROR | 20 (40 μL) | 200 μL |
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| GRIA4-NAALAD2-20-GRGO | 20 (40 μL) | 200 μL |
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| GRIA4-NAALAD2-20-GRGR | 20 (40 μL) | 200 μL |
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| GRIA4-NAALAD2-20-GRAQ | 20 (40 μL) | 200 μL |
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| GRIA4-NAALAD2-20-AQRE | 20 (40 μL) | 200 μL |
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| GRIA4-NAALAD2-20-AQOR | 20 (40 μL) | 200 μL |
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| GRIA4-NAALAD2-20-AQGO | 20 (40 μL) | 200 μL |
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| GRIA4-NAALAD2-20-AQGR | 20 (40 μL) | 200 μL |
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| GRIA4-NAALAD2-20-AQAQ | 20 (40 μL) | 200 μL |
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GRIA4 Gene Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]
Gene Name: Glutamate Ionotropic Receptor AMPA Type Subunit 4
Chromosome: CHR11: 105480799 -105852819
Locus: 11q22.3
NAALAD2 Gene Summary
This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves N-acetyl-L-aspartate-L-glutamate (NAAG), which is a neuropeptide expressed both in the central nervous systems and in the periphery and is thought to function as a neurotransmitter. The product of this gene is a type II integral membrane protein. Transient transfection of this gene confers both NAALADase and dipetidyl peptidase IV activities to mammalian cells. This gene is highly expressed in ovary and testis as well as within discrete brain areas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Name: N-acetylated Alpha-linked Acidic Dipeptidase 2
Chromosome: CHR11: 89867817 -89925779
Locus: 11q14.3
Gene Diseases
The GRIA4 NAALAD2 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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