GREB1-PDE1A Fusion FISH Probe
The GREB1-PDE1A Fusion FISH Probe is used to confirm a fusion of the GREB1 and PDE1A genes. The fusion of the GREB1 and PDE1A genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GREB1-PDE1A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GREB1-PDE1A-20-RERE | 20 (40 μL) | 200 μL |
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| GREB1-PDE1A-20-REOR | 20 (40 μL) | 200 μL |
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| GREB1-PDE1A-20-REGO | 20 (40 μL) | 200 μL |
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| GREB1-PDE1A-20-REGR | 20 (40 μL) | 200 μL |
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| GREB1-PDE1A-20-REAQ | 20 (40 μL) | 200 μL |
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| GREB1-PDE1A-20-ORRE | 20 (40 μL) | 200 μL |
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| GREB1-PDE1A-20-OROR | 20 (40 μL) | 200 μL |
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| GREB1-PDE1A-20-ORGO | 20 (40 μL) | 200 μL |
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| GREB1-PDE1A-20-ORAQ | 20 (40 μL) | 200 μL |
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| GREB1-PDE1A-20-GORE | 20 (40 μL) | 200 μL |
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| GREB1-PDE1A-20-GOOR | 20 (40 μL) | 200 μL |
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| GREB1-PDE1A-20-GOGO | 20 (40 μL) | 200 μL |
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| GREB1-PDE1A-20-GOGR | 20 (40 μL) | 200 μL |
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| GREB1-PDE1A-20-GOAQ | 20 (40 μL) | 200 μL |
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| GREB1-PDE1A-20-GRRE | 20 (40 μL) | 200 μL |
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| GREB1-PDE1A-20-GROR | 20 (40 μL) | 200 μL |
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| GREB1-PDE1A-20-GRGO | 20 (40 μL) | 200 μL |
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| GREB1-PDE1A-20-GRGR | 20 (40 μL) | 200 μL |
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| GREB1-PDE1A-20-GRAQ | 20 (40 μL) | 200 μL |
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| GREB1-PDE1A-20-AQRE | 20 (40 μL) | 200 μL |
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| GREB1-PDE1A-20-AQOR | 20 (40 μL) | 200 μL |
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| GREB1-PDE1A-20-AQGO | 20 (40 μL) | 200 μL |
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| GREB1-PDE1A-20-AQGR | 20 (40 μL) | 200 μL |
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| GREB1-PDE1A-20-AQAQ | 20 (40 μL) | 200 μL |
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PDE1A Gene Summary
Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009]
Gene Name: Phosphodiesterase 1A
Chromosome: CHR2: 183007182 -183387253
Locus: 2q32.1
GREB1 Gene Summary
This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Growth Regulation By Estrogen In Breast Cancer 1
Chromosome: CHR2: 11674241 -11782912
Locus: 2p25.1
Gene Diseases
The GREB1 PDE1A Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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