GPX4-SEC63 Fusion FISH Probe
The GPX4-SEC63 Fusion FISH Probe is used to confirm a fusion of the GPX4 and SEC63 genes. The fusion of the GPX4 and SEC63 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GPX4-SEC63-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GPX4-SEC63-20-RERE | 20 (40 μL) | 200 μL |
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| GPX4-SEC63-20-REOR | 20 (40 μL) | 200 μL |
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| GPX4-SEC63-20-REGO | 20 (40 μL) | 200 μL |
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| GPX4-SEC63-20-REGR | 20 (40 μL) | 200 μL |
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| GPX4-SEC63-20-REAQ | 20 (40 μL) | 200 μL |
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| GPX4-SEC63-20-ORRE | 20 (40 μL) | 200 μL |
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| GPX4-SEC63-20-OROR | 20 (40 μL) | 200 μL |
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| GPX4-SEC63-20-ORGO | 20 (40 μL) | 200 μL |
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| GPX4-SEC63-20-ORAQ | 20 (40 μL) | 200 μL |
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| GPX4-SEC63-20-GORE | 20 (40 μL) | 200 μL |
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| GPX4-SEC63-20-GOOR | 20 (40 μL) | 200 μL |
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| GPX4-SEC63-20-GOGO | 20 (40 μL) | 200 μL |
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| GPX4-SEC63-20-GOGR | 20 (40 μL) | 200 μL |
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| GPX4-SEC63-20-GOAQ | 20 (40 μL) | 200 μL |
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| GPX4-SEC63-20-GRRE | 20 (40 μL) | 200 μL |
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| GPX4-SEC63-20-GROR | 20 (40 μL) | 200 μL |
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| GPX4-SEC63-20-GRGO | 20 (40 μL) | 200 μL |
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| GPX4-SEC63-20-GRGR | 20 (40 μL) | 200 μL |
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| GPX4-SEC63-20-GRAQ | 20 (40 μL) | 200 μL |
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| GPX4-SEC63-20-AQRE | 20 (40 μL) | 200 μL |
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| GPX4-SEC63-20-AQOR | 20 (40 μL) | 200 μL |
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| GPX4-SEC63-20-AQGO | 20 (40 μL) | 200 μL |
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| GPX4-SEC63-20-AQGR | 20 (40 μL) | 200 μL |
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| GPX4-SEC63-20-AQAQ | 20 (40 μL) | 200 μL |
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GPX4 Gene Summary
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]
Gene Name: Glutathione Peroxidase 4
Chromosome: CHR19: 1103935 -1106787
Locus: 19p13.3
SEC63 Gene Summary
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Gene Name: SEC63 Homolog, Protein Translocation Regulator
Chromosome: CHR6: 108188959 -108279482
Locus: 6q21
Gene Diseases
The GPX4 SEC63 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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