GPSM1-NUP214 Fusion FISH Probe
The GPSM1-NUP214 Fusion FISH Probe is used to confirm a fusion of the GPSM1 and NUP214 genes. The fusion of the GPSM1 and NUP214 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GPSM1-NUP214-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GPSM1-NUP214-20-RERE | 20 (40 μL) | 200 μL |
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| GPSM1-NUP214-20-REOR | 20 (40 μL) | 200 μL |
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| GPSM1-NUP214-20-REGO | 20 (40 μL) | 200 μL |
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| GPSM1-NUP214-20-REGR | 20 (40 μL) | 200 μL |
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| GPSM1-NUP214-20-REAQ | 20 (40 μL) | 200 μL |
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| GPSM1-NUP214-20-ORRE | 20 (40 μL) | 200 μL |
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| GPSM1-NUP214-20-OROR | 20 (40 μL) | 200 μL |
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| GPSM1-NUP214-20-ORGO | 20 (40 μL) | 200 μL |
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| GPSM1-NUP214-20-ORAQ | 20 (40 μL) | 200 μL |
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| GPSM1-NUP214-20-GORE | 20 (40 μL) | 200 μL |
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| GPSM1-NUP214-20-GOOR | 20 (40 μL) | 200 μL |
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| GPSM1-NUP214-20-GOGO | 20 (40 μL) | 200 μL |
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| GPSM1-NUP214-20-GOGR | 20 (40 μL) | 200 μL |
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| GPSM1-NUP214-20-GOAQ | 20 (40 μL) | 200 μL |
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| GPSM1-NUP214-20-GRRE | 20 (40 μL) | 200 μL |
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| GPSM1-NUP214-20-GROR | 20 (40 μL) | 200 μL |
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| GPSM1-NUP214-20-GRGO | 20 (40 μL) | 200 μL |
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| GPSM1-NUP214-20-GRGR | 20 (40 μL) | 200 μL |
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| GPSM1-NUP214-20-GRAQ | 20 (40 μL) | 200 μL |
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| GPSM1-NUP214-20-AQRE | 20 (40 μL) | 200 μL |
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| GPSM1-NUP214-20-AQOR | 20 (40 μL) | 200 μL |
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| GPSM1-NUP214-20-AQGO | 20 (40 μL) | 200 μL |
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| GPSM1-NUP214-20-AQGR | 20 (40 μL) | 200 μL |
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| GPSM1-NUP214-20-AQAQ | 20 (40 μL) | 200 μL |
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NUP214 Gene Summary
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Gene Name: Nucleoporin 214
Chromosome: CHR9: 134000980 -134109091
Locus: 9q34.13
GPSM1 Gene Summary
G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Name: G Protein Signaling Modulator 1
Chromosome: CHR9: 139221931 -139254057
Locus: 9q34.3
Gene Diseases
The GPSM1 NUP214 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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