GPNMB-IRF6 Fusion FISH Probe
The GPNMB-IRF6 Fusion FISH Probe is used to confirm a fusion of the GPNMB and IRF6 genes. The fusion of the GPNMB and IRF6 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GPNMB-IRF6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GPNMB-IRF6-20-RERE | 20 (40 μL) | 200 μL |
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| GPNMB-IRF6-20-REOR | 20 (40 μL) | 200 μL |
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| GPNMB-IRF6-20-REGO | 20 (40 μL) | 200 μL |
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| GPNMB-IRF6-20-REGR | 20 (40 μL) | 200 μL |
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| GPNMB-IRF6-20-REAQ | 20 (40 μL) | 200 μL |
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| GPNMB-IRF6-20-ORRE | 20 (40 μL) | 200 μL |
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| GPNMB-IRF6-20-OROR | 20 (40 μL) | 200 μL |
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| GPNMB-IRF6-20-ORGO | 20 (40 μL) | 200 μL |
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| GPNMB-IRF6-20-ORAQ | 20 (40 μL) | 200 μL |
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| GPNMB-IRF6-20-GORE | 20 (40 μL) | 200 μL |
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| GPNMB-IRF6-20-GOOR | 20 (40 μL) | 200 μL |
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| GPNMB-IRF6-20-GOGO | 20 (40 μL) | 200 μL |
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| GPNMB-IRF6-20-GOGR | 20 (40 μL) | 200 μL |
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| GPNMB-IRF6-20-GOAQ | 20 (40 μL) | 200 μL |
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| GPNMB-IRF6-20-GRRE | 20 (40 μL) | 200 μL |
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| GPNMB-IRF6-20-GROR | 20 (40 μL) | 200 μL |
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| GPNMB-IRF6-20-GRGO | 20 (40 μL) | 200 μL |
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| GPNMB-IRF6-20-GRGR | 20 (40 μL) | 200 μL |
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| GPNMB-IRF6-20-GRAQ | 20 (40 μL) | 200 μL |
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| GPNMB-IRF6-20-AQRE | 20 (40 μL) | 200 μL |
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| GPNMB-IRF6-20-AQOR | 20 (40 μL) | 200 μL |
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| GPNMB-IRF6-20-AQGO | 20 (40 μL) | 200 μL |
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| GPNMB-IRF6-20-AQGR | 20 (40 μL) | 200 μL |
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| GPNMB-IRF6-20-AQAQ | 20 (40 μL) | 200 μL |
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IRF6 Gene Summary
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2011]
Gene Name: Interferon Regulatory Factor 6
Chromosome: CHR1: 209958967 -209979520
Locus: 1q32.2
GPNMB Gene Summary
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Glycoprotein Nmb
Chromosome: CHR7: 23286315 -23314729
Locus: 7p15.3
Gene Diseases
The GPNMB IRF6 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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