GPLD1-TDP2 Fusion FISH Probe
The GPLD1-TDP2 Fusion FISH Probe is used to confirm a fusion of the GPLD1 and TDP2 genes. The fusion of the GPLD1 and TDP2 genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GPLD1-TDP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GPLD1-TDP2-20-RERE | 20 (40 μL) | 200 μL |
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| GPLD1-TDP2-20-REOR | 20 (40 μL) | 200 μL |
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| GPLD1-TDP2-20-REGO | 20 (40 μL) | 200 μL |
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| GPLD1-TDP2-20-REGR | 20 (40 μL) | 200 μL |
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| GPLD1-TDP2-20-REAQ | 20 (40 μL) | 200 μL |
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| GPLD1-TDP2-20-ORRE | 20 (40 μL) | 200 μL |
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| GPLD1-TDP2-20-OROR | 20 (40 μL) | 200 μL |
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| GPLD1-TDP2-20-ORGO | 20 (40 μL) | 200 μL |
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| GPLD1-TDP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| GPLD1-TDP2-20-GORE | 20 (40 μL) | 200 μL |
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| GPLD1-TDP2-20-GOOR | 20 (40 μL) | 200 μL |
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| GPLD1-TDP2-20-GOGO | 20 (40 μL) | 200 μL |
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| GPLD1-TDP2-20-GOGR | 20 (40 μL) | 200 μL |
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| GPLD1-TDP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| GPLD1-TDP2-20-GRRE | 20 (40 μL) | 200 μL |
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| GPLD1-TDP2-20-GROR | 20 (40 μL) | 200 μL |
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| GPLD1-TDP2-20-GRGO | 20 (40 μL) | 200 μL |
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| GPLD1-TDP2-20-GRGR | 20 (40 μL) | 200 μL |
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| GPLD1-TDP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| GPLD1-TDP2-20-AQRE | 20 (40 μL) | 200 μL |
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| GPLD1-TDP2-20-AQOR | 20 (40 μL) | 200 μL |
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| GPLD1-TDP2-20-AQGO | 20 (40 μL) | 200 μL |
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| GPLD1-TDP2-20-AQGR | 20 (40 μL) | 200 μL |
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| GPLD1-TDP2-20-AQAQ | 20 (40 μL) | 200 μL |
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GPLD1 Gene Summary
Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008]
Gene Name: Glycosylphosphatidylinositol Specific Phospholipase D1
Chromosome: CHR6: 24428404 -24489850
Locus: 6p22.3
TDP2 Gene Summary
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008]
Gene Name: Tyrosyl-DNA Phosphodiesterase 2
Chromosome: CHR6: 24650204 -24667115
Locus: 6p22.3
Gene Diseases
The GPLD1 TDP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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