GPBP1-MTRR Fusion FISH Probe
The GPBP1-MTRR Fusion FISH Probe is used to confirm a fusion of the GPBP1 and MTRR genes. The fusion of the GPBP1 and MTRR genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GPBP1-MTRR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GPBP1-MTRR-20-RERE | 20 (40 μL) | 200 μL |
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| GPBP1-MTRR-20-REOR | 20 (40 μL) | 200 μL |
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| GPBP1-MTRR-20-REGO | 20 (40 μL) | 200 μL |
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| GPBP1-MTRR-20-REGR | 20 (40 μL) | 200 μL |
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| GPBP1-MTRR-20-REAQ | 20 (40 μL) | 200 μL |
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| GPBP1-MTRR-20-ORRE | 20 (40 μL) | 200 μL |
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| GPBP1-MTRR-20-OROR | 20 (40 μL) | 200 μL |
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| GPBP1-MTRR-20-ORGO | 20 (40 μL) | 200 μL |
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| GPBP1-MTRR-20-ORAQ | 20 (40 μL) | 200 μL |
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| GPBP1-MTRR-20-GORE | 20 (40 μL) | 200 μL |
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| GPBP1-MTRR-20-GOOR | 20 (40 μL) | 200 μL |
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| GPBP1-MTRR-20-GOGO | 20 (40 μL) | 200 μL |
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| GPBP1-MTRR-20-GOGR | 20 (40 μL) | 200 μL |
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| GPBP1-MTRR-20-GOAQ | 20 (40 μL) | 200 μL |
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| GPBP1-MTRR-20-GRRE | 20 (40 μL) | 200 μL |
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| GPBP1-MTRR-20-GROR | 20 (40 μL) | 200 μL |
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| GPBP1-MTRR-20-GRGO | 20 (40 μL) | 200 μL |
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| GPBP1-MTRR-20-GRGR | 20 (40 μL) | 200 μL |
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| GPBP1-MTRR-20-GRAQ | 20 (40 μL) | 200 μL |
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| GPBP1-MTRR-20-AQRE | 20 (40 μL) | 200 μL |
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| GPBP1-MTRR-20-AQOR | 20 (40 μL) | 200 μL |
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| GPBP1-MTRR-20-AQGO | 20 (40 μL) | 200 μL |
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| GPBP1-MTRR-20-AQGR | 20 (40 μL) | 200 μL |
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| GPBP1-MTRR-20-AQAQ | 20 (40 μL) | 200 μL |
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MTRR Gene Summary
This gene encodes a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. This protein functions in the synthesis of methionine by regenerating methionine synthase to a functional state. Because methionine synthesis requires methyl-group transfer by a folate donor, activity of the encoded enzyme is important for folate metabolism and cellular methylation. Mutations in this gene can cause homocystinuria-megaloblastic anemia, cbl E type. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Gene Name: 5-methyltetrahydrofolate-homocysteine Methyltransferase Reductase
Chromosome: CHR5: 7869216 -7901235
Locus: 5p15.31
GPBP1 Gene Summary
This gene was originally isolated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells. However, a shorter splice variant was found to be more ubiquitously expressed. This protein is suggested to play a role in the development of atherosclerosis. Studies in mice suggest that it may also function as a GC-rich promoter-specific trans-activating transcription factor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Gene Name: GC-rich Promoter Binding Protein 1
Chromosome: CHR5: 56469774 -56560506
Locus: 5q11.2
Gene Diseases
The GPBP1 MTRR Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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