GPBP1-BDNF Fusion FISH Probe
The GPBP1-BDNF Fusion FISH Probe is used to confirm a fusion of the GPBP1 and BDNF genes. The fusion of the GPBP1 and BDNF genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GPBP1-BDNF-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GPBP1-BDNF-20-RERE | 20 (40 μL) | 200 μL |
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| GPBP1-BDNF-20-REOR | 20 (40 μL) | 200 μL |
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| GPBP1-BDNF-20-REGO | 20 (40 μL) | 200 μL |
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| GPBP1-BDNF-20-REGR | 20 (40 μL) | 200 μL |
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| GPBP1-BDNF-20-REAQ | 20 (40 μL) | 200 μL |
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| GPBP1-BDNF-20-ORRE | 20 (40 μL) | 200 μL |
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| GPBP1-BDNF-20-OROR | 20 (40 μL) | 200 μL |
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| GPBP1-BDNF-20-ORGO | 20 (40 μL) | 200 μL |
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| GPBP1-BDNF-20-ORAQ | 20 (40 μL) | 200 μL |
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| GPBP1-BDNF-20-GORE | 20 (40 μL) | 200 μL |
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| GPBP1-BDNF-20-GOOR | 20 (40 μL) | 200 μL |
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| GPBP1-BDNF-20-GOGO | 20 (40 μL) | 200 μL |
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| GPBP1-BDNF-20-GOGR | 20 (40 μL) | 200 μL |
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| GPBP1-BDNF-20-GOAQ | 20 (40 μL) | 200 μL |
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| GPBP1-BDNF-20-GRRE | 20 (40 μL) | 200 μL |
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| GPBP1-BDNF-20-GROR | 20 (40 μL) | 200 μL |
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| GPBP1-BDNF-20-GRGO | 20 (40 μL) | 200 μL |
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| GPBP1-BDNF-20-GRGR | 20 (40 μL) | 200 μL |
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| GPBP1-BDNF-20-GRAQ | 20 (40 μL) | 200 μL |
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| GPBP1-BDNF-20-AQRE | 20 (40 μL) | 200 μL |
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| GPBP1-BDNF-20-AQOR | 20 (40 μL) | 200 μL |
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| GPBP1-BDNF-20-AQGO | 20 (40 μL) | 200 μL |
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| GPBP1-BDNF-20-AQGR | 20 (40 μL) | 200 μL |
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| GPBP1-BDNF-20-AQAQ | 20 (40 μL) | 200 μL |
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BDNF Gene Summary
This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015]
Gene Name: Brain Derived Neurotrophic Factor
Chromosome: CHR11: 27676441 -27743605
Locus: 11p14.1
GPBP1 Gene Summary
This gene was originally isolated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells. However, a shorter splice variant was found to be more ubiquitously expressed. This protein is suggested to play a role in the development of atherosclerosis. Studies in mice suggest that it may also function as a GC-rich promoter-specific trans-activating transcription factor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Gene Name: GC-rich Promoter Binding Protein 1
Chromosome: CHR5: 56469774 -56560506
Locus: 5q11.2
Gene Diseases
The GPBP1 BDNF Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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