GOT2-MMP2 Fusion FISH Probe
The GOT2-MMP2 Fusion FISH Probe is used to confirm a fusion of the GOT2 and MMP2 genes. The fusion of the GOT2 and MMP2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GOT2-MMP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GOT2-MMP2-20-RERE | 20 (40 μL) | 200 μL |
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| GOT2-MMP2-20-REOR | 20 (40 μL) | 200 μL |
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| GOT2-MMP2-20-REGO | 20 (40 μL) | 200 μL |
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| GOT2-MMP2-20-REGR | 20 (40 μL) | 200 μL |
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| GOT2-MMP2-20-REAQ | 20 (40 μL) | 200 μL |
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| GOT2-MMP2-20-ORRE | 20 (40 μL) | 200 μL |
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| GOT2-MMP2-20-OROR | 20 (40 μL) | 200 μL |
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| GOT2-MMP2-20-ORGO | 20 (40 μL) | 200 μL |
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| GOT2-MMP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| GOT2-MMP2-20-GORE | 20 (40 μL) | 200 μL |
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| GOT2-MMP2-20-GOOR | 20 (40 μL) | 200 μL |
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| GOT2-MMP2-20-GOGO | 20 (40 μL) | 200 μL |
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| GOT2-MMP2-20-GOGR | 20 (40 μL) | 200 μL |
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| GOT2-MMP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| GOT2-MMP2-20-GRRE | 20 (40 μL) | 200 μL |
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| GOT2-MMP2-20-GROR | 20 (40 μL) | 200 μL |
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| GOT2-MMP2-20-GRGO | 20 (40 μL) | 200 μL |
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| GOT2-MMP2-20-GRGR | 20 (40 μL) | 200 μL |
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| GOT2-MMP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| GOT2-MMP2-20-AQRE | 20 (40 μL) | 200 μL |
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| GOT2-MMP2-20-AQOR | 20 (40 μL) | 200 μL |
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| GOT2-MMP2-20-AQGO | 20 (40 μL) | 200 μL |
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| GOT2-MMP2-20-AQGR | 20 (40 μL) | 200 μL |
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| GOT2-MMP2-20-AQAQ | 20 (40 μL) | 200 μL |
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GOT2 Gene Summary
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Gene Name: Glutamic-oxaloacetic Transaminase 2
Chromosome: CHR16: 58741034 -58768246
Locus: 16q21
MMP2 Gene Summary
This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Gene Name: Matrix Metallopeptidase 2
Chromosome: CHR16: 55513080 -55540586
Locus: 16q12.2
Gene Diseases
The GOT2 MMP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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