GOLPH3-IKZF3 Fusion FISH Probe
The GOLPH3-IKZF3 Fusion FISH Probe is used to confirm a fusion of the GOLPH3 and IKZF3 genes. The fusion of the GOLPH3 and IKZF3 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GOLPH3-IKZF3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GOLPH3-IKZF3-20-RERE | 20 (40 μL) | 200 μL |
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| GOLPH3-IKZF3-20-REOR | 20 (40 μL) | 200 μL |
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| GOLPH3-IKZF3-20-REGO | 20 (40 μL) | 200 μL |
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| GOLPH3-IKZF3-20-REGR | 20 (40 μL) | 200 μL |
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| GOLPH3-IKZF3-20-REAQ | 20 (40 μL) | 200 μL |
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| GOLPH3-IKZF3-20-ORRE | 20 (40 μL) | 200 μL |
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| GOLPH3-IKZF3-20-OROR | 20 (40 μL) | 200 μL |
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| GOLPH3-IKZF3-20-ORGO | 20 (40 μL) | 200 μL |
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| GOLPH3-IKZF3-20-ORAQ | 20 (40 μL) | 200 μL |
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| GOLPH3-IKZF3-20-GORE | 20 (40 μL) | 200 μL |
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| GOLPH3-IKZF3-20-GOOR | 20 (40 μL) | 200 μL |
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| GOLPH3-IKZF3-20-GOGO | 20 (40 μL) | 200 μL |
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| GOLPH3-IKZF3-20-GOGR | 20 (40 μL) | 200 μL |
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| GOLPH3-IKZF3-20-GOAQ | 20 (40 μL) | 200 μL |
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| GOLPH3-IKZF3-20-GRRE | 20 (40 μL) | 200 μL |
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| GOLPH3-IKZF3-20-GROR | 20 (40 μL) | 200 μL |
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| GOLPH3-IKZF3-20-GRGO | 20 (40 μL) | 200 μL |
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| GOLPH3-IKZF3-20-GRGR | 20 (40 μL) | 200 μL |
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| GOLPH3-IKZF3-20-GRAQ | 20 (40 μL) | 200 μL |
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| GOLPH3-IKZF3-20-AQRE | 20 (40 μL) | 200 μL |
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| GOLPH3-IKZF3-20-AQOR | 20 (40 μL) | 200 μL |
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| GOLPH3-IKZF3-20-AQGO | 20 (40 μL) | 200 μL |
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| GOLPH3-IKZF3-20-AQGR | 20 (40 μL) | 200 μL |
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| GOLPH3-IKZF3-20-AQAQ | 20 (40 μL) | 200 μL |
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IKZF3 Gene Summary
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]
Gene Name: IKAROS Family Zinc Finger 3
Chromosome: CHR17: 37921198 -38020441
Locus: 17q12-q21.1
GOLPH3 Gene Summary
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a peripheral membrane protein of the Golgi stack and may have a regulatory role in Golgi trafficking. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Golgi Phosphoprotein 3
Chromosome: CHR5: 32124823 -32174425
Locus: 5p13.3
Gene Diseases
The GOLPH3 IKZF3 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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