GOLGA4-MLH1 Fusion FISH Probe
The GOLGA4-MLH1 Fusion FISH Probe is used to confirm a fusion of the GOLGA4 and MLH1 genes. The fusion of the GOLGA4 and MLH1 genes has been associated with Stomach Adenocarcinoma, and Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GOLGA4-MLH1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GOLGA4-MLH1-20-RERE | 20 (40 μL) | 200 μL |
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| GOLGA4-MLH1-20-REOR | 20 (40 μL) | 200 μL |
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| GOLGA4-MLH1-20-REGO | 20 (40 μL) | 200 μL |
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| GOLGA4-MLH1-20-REGR | 20 (40 μL) | 200 μL |
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| GOLGA4-MLH1-20-REAQ | 20 (40 μL) | 200 μL |
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| GOLGA4-MLH1-20-ORRE | 20 (40 μL) | 200 μL |
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| GOLGA4-MLH1-20-OROR | 20 (40 μL) | 200 μL |
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| GOLGA4-MLH1-20-ORGO | 20 (40 μL) | 200 μL |
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| GOLGA4-MLH1-20-ORAQ | 20 (40 μL) | 200 μL |
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| GOLGA4-MLH1-20-GORE | 20 (40 μL) | 200 μL |
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| GOLGA4-MLH1-20-GOOR | 20 (40 μL) | 200 μL |
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| GOLGA4-MLH1-20-GOGO | 20 (40 μL) | 200 μL |
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| GOLGA4-MLH1-20-GOGR | 20 (40 μL) | 200 μL |
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| GOLGA4-MLH1-20-GOAQ | 20 (40 μL) | 200 μL |
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| GOLGA4-MLH1-20-GRRE | 20 (40 μL) | 200 μL |
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| GOLGA4-MLH1-20-GROR | 20 (40 μL) | 200 μL |
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| GOLGA4-MLH1-20-GRGO | 20 (40 μL) | 200 μL |
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| GOLGA4-MLH1-20-GRGR | 20 (40 μL) | 200 μL |
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| GOLGA4-MLH1-20-GRAQ | 20 (40 μL) | 200 μL |
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| GOLGA4-MLH1-20-AQRE | 20 (40 μL) | 200 μL |
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| GOLGA4-MLH1-20-AQOR | 20 (40 μL) | 200 μL |
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| GOLGA4-MLH1-20-AQGO | 20 (40 μL) | 200 μL |
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| GOLGA4-MLH1-20-AQGR | 20 (40 μL) | 200 μL |
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| GOLGA4-MLH1-20-AQAQ | 20 (40 μL) | 200 μL |
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GOLGA4 Gene Summary
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]
Gene Name: Golgin A4
Chromosome: CHR3: 37284681 -37408370
Locus: 3p22.2
MLH1 Gene Summary
The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]
Gene Name: MutL Homolog 1
Chromosome: CHR3: 37034840 -37092337
Locus: 3p22.2
Gene Diseases
The GOLGA4 MLH1 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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