GNRHR2-S100A13 Fusion FISH Probe
The GNRHR2-S100A13 Fusion FISH Probe is used to confirm a fusion of the GNRHR2 and S100A13 genes. The fusion of the GNRHR2 and S100A13 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GNRHR2-S100A13-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GNRHR2-S100A13-20-RERE | 20 (40 μL) | 200 μL |
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| GNRHR2-S100A13-20-REOR | 20 (40 μL) | 200 μL |
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| GNRHR2-S100A13-20-REGO | 20 (40 μL) | 200 μL |
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| GNRHR2-S100A13-20-REGR | 20 (40 μL) | 200 μL |
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| GNRHR2-S100A13-20-REAQ | 20 (40 μL) | 200 μL |
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| GNRHR2-S100A13-20-ORRE | 20 (40 μL) | 200 μL |
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| GNRHR2-S100A13-20-OROR | 20 (40 μL) | 200 μL |
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| GNRHR2-S100A13-20-ORGO | 20 (40 μL) | 200 μL |
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| GNRHR2-S100A13-20-ORAQ | 20 (40 μL) | 200 μL |
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| GNRHR2-S100A13-20-GORE | 20 (40 μL) | 200 μL |
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| GNRHR2-S100A13-20-GOOR | 20 (40 μL) | 200 μL |
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| GNRHR2-S100A13-20-GOGO | 20 (40 μL) | 200 μL |
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| GNRHR2-S100A13-20-GOGR | 20 (40 μL) | 200 μL |
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| GNRHR2-S100A13-20-GOAQ | 20 (40 μL) | 200 μL |
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| GNRHR2-S100A13-20-GRRE | 20 (40 μL) | 200 μL |
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| GNRHR2-S100A13-20-GROR | 20 (40 μL) | 200 μL |
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| GNRHR2-S100A13-20-GRGO | 20 (40 μL) | 200 μL |
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| GNRHR2-S100A13-20-GRGR | 20 (40 μL) | 200 μL |
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| GNRHR2-S100A13-20-GRAQ | 20 (40 μL) | 200 μL |
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| GNRHR2-S100A13-20-AQRE | 20 (40 μL) | 200 μL |
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| GNRHR2-S100A13-20-AQOR | 20 (40 μL) | 200 μL |
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| GNRHR2-S100A13-20-AQGO | 20 (40 μL) | 200 μL |
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| GNRHR2-S100A13-20-AQGR | 20 (40 μL) | 200 μL |
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| GNRHR2-S100A13-20-AQAQ | 20 (40 μL) | 200 μL |
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S100A13 Gene Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: S100 Calcium Binding Protein A13
Chromosome: CHR1: 153591275 -153606568
Locus: 1q21.3
GNRHR2 Gene Summary
In non-hominoid primates and non-mammalian vertebrates, the gonadotropin releasing hormone 2 receptor gene (GnRHR2) encodes a seven-transmembrane G-protein coupled receptor. However, in human, the corresponding reading frame contains a premature stop codon, which has been suggested to encode a selenocysteine residue, but there is no solid evidence for selenocysteine incorporation (PMID: 12538601). It appears that the human GnRHR2 transcription occurs but the gene does not likely produce a functional multi-transmembrane protein. A non-transcribed pseudogene of GnRHR2 is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2013]
Gene Name: Gonadotropin Releasing Hormone Receptor 2 (pseudogene)
Chromosome: CHR1: 145509819 -145516076
Locus: 1q21.1
Gene Diseases
The GNRHR2 S100A13 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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